Burkholderia cenocepacia J2315, BCAS0364

Cytoplasmic Membrane
Outer Membrane
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
NCBI Locus TagQU43_RS70495
Synonym: PaaZ-ECH
Replicon chromosome 3
Genomic location 425261 - 425719 (+ strand)
CommentIn E. coli, paaZ encodes a bifunctional protein consisting of an N-terminal NADP-dependent aldehyde dehydrogenase domain and a C-terminal MaoC-like (R)-specific enoyl-CoA hydratase domain. In Burkholderia genomes, a gene incorrectly annotated as paaZ (e.g WQ49_RS11500) encodes only one of the two domains found in E.coli paaZ (the domain with semialdehyde dehydrogenase activity) and so is renamed PacL (PMID:21296885) but was also referred to as PaaZ-ALDH in the manuscript. In the same study , a separate A. aromaticum, protein (UniProtKB:Q5P232) with the (R)-hydratase activity was annotated as Ech-Aa and the Burkholderia ortholog was annotated as PaaZ-ECH.


RefSeq WP_006483300.1
GI 197295213
Entrez 6804256
GI 197295213
INSDC CAR57296.1
NCBI Locus Tag QU43_RS70495
NCBI Old Locus Tag BCAS0364
RefSeq WP_006483300.1,GeneID
UniParc UPI00017BB15C
UniProtKB Acc B4ENB4
UniRef100 UniRef100_A0A0D1DMC8
UniRef50 UniRef50_Q89GF1
UniRef90 UniRef90_A0A095EIA7


Feature Type CDS
Coding Frame 1
Product Name
putative (R)-specific oxepin-CoA hydratase
Product Name Confidence: Class 2
Synonyms putative maoC domain protein
Evidence for Translation
Charge (pH 7) -2.63
Kyte-Doolittle Hydrophobicity Value -0.153
Molecular Weight (kDa) 16901.1
Isoelectric Point (pI) 6.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 253 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005317 (313 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BCAS0364

Human Homologs


Studies on the mechanism of ring hydrolysis in phenylacetate degradation: a metabolic branching point.
Teufel R, Gantert C, Voss M, Eisenreich W, Haehnel W, Fuchs G
J Biol Chem 2011 Apr 1;286(13):11021-34
PubMed ID: 21296885