Burkholderia cenocepacia J2315, BCAS0364

Cytoplasmic Membrane
Outer Membrane
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Annotation Updates

Date Description Acknowledgements
Apr 30, 2018 New product name: putative (R)-specific oxepin-CoA hydratase. New product name synonym: PaaZ-ECH. New product name confidence: Class 2. New PubMed ID: 21296885. New comment: in E coli, paaZ encodes a bifunctional protein consisting of an N-terminal NADP-dependent aldehyde dehydrogenase domain and a C-terminal MaoC-like (R)-specific enoyl-CoA hydratase domain. In Burkholderia genomes, a gene incorrectly annotated as paaZ (e.g WQ49_RS11500) encodes only one of the two domains found in E.coli paaZ (the domain with semialdehyde dehydrogenase activity) and so is renamed PacL (PMID:21296885) but was also referred to as PaaZ-ALDH in the manuscript. In the same study , a separate A. aromaticum, protein (UniProtKB:Q5P232) with the (R)-hydratase activity was annotated as Ech-Aa and the Burkholderia ortholog was annotated as PaaZ-ECH. . Annotation transferred from: UniProtKB:Q5P232. Dustin Lavallee and Silvia Cardona, University of Manitoba