Burkholderia pseudomallei 668, BURPS668_A2163 (bicA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 668
GCF_000015905.1|latest
Locus Tag
BURPS668_A2163
NCBI Locus TagBURPS668_RS25905
Name
bicA
Replicon chromosome II
Genomic location 2101122 - 2101637 (- strand)

Cross-References

RefSeq WP_004525319.1
GI 126444531
Entrez 4886644
GI 126444531
INSDC ABN87527.1
NCBI Locus Tag BURPS668_RS25905
NCBI Old Locus Tag BURPS668_A2163
RefSeq WP_004525319.1
UniParc UPI00005598BA
UniProtKB Acc A3NLD6
UniProtKB ID A3NLD6_BURP6
UniRef100 UniRef100_I1WUC1
UniRef50 UniRef50_Q7NUS7
UniRef90 UniRef90_I1WUC1

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion, low calcium response chaperone LcrH/SycD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -7.93
Kyte-Doolittle Hydrophobicity Value -0.242
Molecular Weight (kDa) 19170.4
Isoelectric Point (pI) 4.71

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 28 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019836 (323 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS668_A2163
Search term: bicA

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Type III secretion chaperone-dependent regulation: activation of virulence genes by SicA and InvF in Salmonella typhimurium.
Darwin KH, Miller VL
EMBO J 2001 Apr 17;20(8):1850-62
PubMed ID: 11296219