Burkholderia dolosa AU0158, AK34_RS06465 (bceN)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia dolosa AU0158 (complete genome)
Locus Tag
NCBI Old Locus TagAK34_4460
Synonym: BDAG_02940
Replicon chromosome 2
Genomic location 1519547 - 1520593 (+ strand)
CommentMember of the bce-II gene cluster


RefSeq WP_006765556.1
GI 493818000
NCBI Locus Tag AK34_RS06465
NCBI Old Locus Tag AK34_4460
RefSeq WP_006765556.1


Feature Type CDS
Coding Frame 1
Product Name
GDP-D-mannose 4,6-dehydratase BceN
Product Name Confidence: Class 2
Synonyms GDP-mannose 4,6-dehydratase
Evidence for Translation
Charge (pH 7) 0.36
Kyte-Doolittle Hydrophobicity Value -0.353
Molecular Weight (kDa) 39100.1
Isoelectric Point (pI) 7.13

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003102 (653 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: AK34_RS06465
Search term: bceN

Human Homologs

Ensembl 97, assembly GRCh38.p12
GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369]
E-value: 1.5e-99
Percent Identity: 53.3


Biochemical and functional studies on the Burkholderia cepacia complex bceN gene, encoding a GDP-D-mannose 4,6-dehydratase.
Sousa SA, Feliciano JR, Pinheiro PF, Leitão JH
PLoS One 2013;8(2):e56902
PubMed ID: 23460819
Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863