Burkholderia pseudomallei K96243, BPSS1620 (bpscV2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1620
Name
bpscV2
Synonym: sctV
Replicon chromosome 2
Genomic location 2194317 - 2196389 (- strand)
CommentThis gene is part of the type III secretion system T3SS-2 locus found in B. pseudomallei. B. pseudomallei T3SS-1 and T3SS-2, but not T3SS-3 contribute to pathogenicity in Solanum lycopersicum (tomato) but not human monocytic cell line THP-1. (PMID:20109238).

Cross-References

RefSeq YP_111628.1
GI 53722643
Entrez 3096418
GI 53722643
INSDC CAH39095.1
NCBI Locus Tag BPSS1620
RefSeq YP_111628.1,GeneID
UniParc UPI000043BD77
UniProtKB Acc Q63JU4
UniProtKB ID Q63JU4_BURPS
UniRef100 UniRef100_Q3JKR5
UniRef50 UniRef50_Q3JKR5
UniRef90 UniRef90_Q3JKR5

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system export apparatus protein BpscV2 (T3SS-2)
Product Name Confidence: Class 2
Synonyms type III secretion protein
Evidence for Translation
Charge (pH 7) -0.66
Kyte-Doolittle Hydrophobicity Value 0.324
Molecular Weight (kDa) 74129.7
Isoelectric Point (pI) 6.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 325 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003804 (592 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1620
Search term: bpscV2

References

Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model.
Warawa J, Woods DE
FEMS Microbiol Lett 2005 Jan 1;242(1):101-8
PubMed ID: 15621426
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152