Burkholderia cenocepacia K56-2, WQ49_RS20305

Cytoplasmic Membrane
Outer Membrane

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2
Locus Tag
NCBI Old Locus TagWQ49_20335
Replicon scf7180000000062
Genomic location 866822 - 870856 (+ strand)
CommentA BCAM0223::Tp mutant was deficient in hemagglutination, affected in adherence to vitronectin and in biofilm formation and showed attenuated virulence in the Galleria mellonella model of infection.


RefSeq WP_034195694.1
GI 736050051
NCBI Locus Tag WQ49_RS20305
NCBI Old Locus Tag WQ49_20335
RefSeq WP_034195694.1


Feature Type CDS
Coding Frame 1
Product Name
vitronectin-binding trimeric autotransporter adhesin
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -60.96
Kyte-Doolittle Hydrophobicity Value -0.100
Molecular Weight (kDa) 132079.1
Isoelectric Point (pI) 4.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG018324 (35 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: WQ49_RS20305

Human Homologs


Trimeric autotransporter adhesins in members of the Burkholderia cepacia complex: a multifunctional family of proteins implicated in virulence.
Mil-Homens D, Fialho AM
Front Cell Infect Microbiol 2011;1:13
PubMed ID: 22919579
A BCAM0223 mutant of Burkholderia cenocepacia is deficient in hemagglutination, serum resistance, adhesion to epithelial cells and virulence.
Mil-Homens D, Fialho AM
PLoS One 2012;7(7):e41747
PubMed ID: 22848588
Genome-wide analysis of DNA repeats in Burkholderia cenocepacia J2315 identifies a novel adhesin-like gene unique to epidemic-associated strains of the ET-12 lineage.
Mil-Homens D, Rocha EPC, Fialho AM
Microbiology 2010 Apr;156(Pt 4):1084-1096
PubMed ID: 20019083