Burkholderia cenocepacia K56-2, WQ49_RS11520 (paaK1)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia cenocepacia K56-2
GCF_000981305.1|latest |
| Locus Tag |
WQ49_RS11520
|
| NCBI Old Locus Tag | WQ49_11525 |
| Name |
paaK1
|
| Replicon | scf7180000000051 |
| Genomic location | 8674 - 9972 (+ strand) |
Cross-References
| RefSeq | WP_006491104.1 |
| GI | 493537174 |
| NCBI Locus Tag | WQ49_RS11520 |
| NCBI Old Locus Tag | WQ49_11525 |
| RefSeq | WP_006491104.1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
PaaK1
|
| Synonyms |
phenylacetate-CoA ligase |
| Evidence for Translation | |
| Charge (pH 7) | -6.12 |
| Kyte-Doolittle Hydrophobicity Value | -0.225 |
| Molecular Weight (kDa) | 47695.1 |
| Isoelectric Point (pI) | 5.71 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2Y27 | LIGASE | 12/13/10 | crystal structure of PaaK1 in complex with ATP from Burkholderia cenocepacia | BURKHOLDERIA CENOCEPACIA | 1.6 | X-RAY DIFFRACTION | 100.0 |
| 2Y4N | LIGASE | 01/07/11 | PaaK1 in complex with phenylacetyl adenylate | BURKHOLDERIA CENOCEPACIA | 1.92 | X-RAY DIFFRACTION | 100.0 |
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG000429 (655 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: WQ49_RS11520
Search term: paaK1
Search term: PaaK1
|
Human Homologs
References
|
Defining a structural and kinetic rationale for paralogous copies of phenylacetate-CoA ligases from the cystic fibrosis pathogen Burkholderia cenocepacia J2315.
Law A, Boulanger MJ
J Biol Chem 2011 Apr 29;286(17):15577-85
PubMed ID: 21388965
|