Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS32320
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest |
| Locus Tag |
BURCENK562V_RS32320
|
| NCBI Old Locus Tag | BURCENK562V_C7175 |
| Name |
Synonym: PaaZ-ECH |
| Replicon | ctg7180000002943 |
| Genomic location | 279396 - 279854 (- strand) |
| Comment | In E. coli, paaZ encodes a bifunctional protein consisting of an N-terminal NADP-dependent aldehyde dehydrogenase domain and a C-terminal MaoC-like (R)-specific enoyl-CoA hydratase domain. In Burkholderia genomes, a gene incorrectly annotated as paaZ (e.g WQ49_RS11500) encodes only one of the two domains found in E.coli paaZ (the domain with semialdehyde dehydrogenase activity) and so is renamed PacL (PMID:21296885) but was also referred to as PaaZ-ALDH in the manuscript. In the same study , a separate A. aromaticum, protein (UniProtKB:Q5P232) with the (R)-hydratase activity was annotated as Ech-Aa and the Burkholderia ortholog was annotated as PaaZ-ECH. |
Cross-References
| RefSeq | WP_006483300.1 |
| GI | 493529284 |
| GI | 493529284 |
| NCBI Locus Tag | BURCENK562V_RS32320 |
| NCBI Old Locus Tag | BURCENK562V_C7175 |
| RefSeq | WP_006483300.1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
putative (R)-specific oxepin-CoA hydratase
|
| Synonyms |
acyl dehydratase |
| Evidence for Translation | |
| Charge (pH 7) | -2.63 |
| Kyte-Doolittle Hydrophobicity Value | -0.153 |
| Molecular Weight (kDa) | 16901.1 |
| Isoelectric Point (pI) | 6.23 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG005317 (313 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: BURCENK562V_RS32320
Search term: putative (R)-specific oxepin-CoA hydratase
|
Human Homologs
References
|
Studies on the mechanism of ring hydrolysis in phenylacetate degradation: a metabolic branching point.
Teufel R, Gantert C, Voss M, Eisenreich W, Haehnel W, Fuchs G
J Biol Chem 2011 Apr 1;286(13):11021-34
PubMed ID: 21296885
|