Strain |
Burkholderia cenocepacia J2315
GCF_000009485.1|latest |
Locus Tag |
BCAL1675
|
NCBI Locus Tag | QU43_RS44900 |
Name |
|
Replicon | chromosome 1 |
Genomic location | 1830038 - 1833178 (+ strand) |
Comment | Member of rnd-3 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-3 |
Comment | Major RND-3 substrates are nalidixic acid, ciprofloxacin, tobramycin, chlorhexidine |
Comment |
RefSeq | WP_006487247.1 |
GI | 206560037 |
Entrez | 6933295 |
GI | 206560037 |
INSDC | CAR51973.1 |
NCBI Locus Tag | QU43_RS44900 |
NCBI Old Locus Tag | BCAL1675 |
RefSeq | WP_006487247.1,GeneID |
UniParc | UPI00017B9281 |
UniProtKB Acc | B4E8U7 |
UniProtKB ID | B4E8U7_BURCJ |
UniRef100 | UniRef100_B4E8U7 |
UniRef50 | UniRef50_P31224 |
UniRef90 | UniRef90_A9AIV5 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
RND-3 efflux system transporter protein
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | 7.17 |
Kyte-Doolittle Hydrophobicity Value | 0.352 |
Molecular Weight (kDa) | 111695.7 |
Isoelectric Point (pI) | 9.14 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
amrB | amrB is the membrane fusion protein of the AmrAB-OprM multidrug efflux complex. | ARO:3002983 | protein homolog model | Strict | 0.0 | 86.6 | 1.2.1 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 487 genera
|
Burkholderia Ortholog Group |
BG001444 (2569 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BCAL1675
Search term: RND-3 efflux system transporter protein
|
Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance.
Buroni S, Pasca MR, Flannagan RS, Bazzini S, Milano A, Bertani I, Venturi V, Valvano MA, Riccardi G
BMC Microbiol 2009 Sep 17;9:200
PubMed ID: 19761586
|
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825
|