Burkholderia cenocepacia J2315, BCAM0531 (mvaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0015936 coenzyme A metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00532
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055114 oxidation-reduction process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00318
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050662 coenzyme binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00532
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00532
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00318
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
MetaCyc mevalonate pathway III (archaea) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc isoprene biosynthesis II (engineered) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc mevalonate pathway I InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc mevalonate pathway II (archaea) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj00900 Terpenoid backbone biosynthesis 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01130 Biosynthesis of antibiotics 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01110 Biosynthesis of secondary metabolites 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG (InterPro) 00900 Terpenoid backbone biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.30.70.420 IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily 110 220 4.6E-134
Gene3D G3DSA:3.90.770.10 IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily 15 372 4.6E-134
PRINTS PR00071 Hydroxymethylglutaryl-coenzyme A reductase signature IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II 313 334 1.4E-5
ProSiteProfiles PS50065 Hydroxymethylglutaryl-coenzyme A reductases family profile. IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II 3 385 39.854
SUPERFAMILY SSF56542 IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily 7 423 6.67E-102
PRINTS PR00071 Hydroxymethylglutaryl-coenzyme A reductase signature IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II 77 97 1.4E-5
ProSitePatterns PS00318 Hydroxymethylglutaryl-coenzyme A reductases signature 2. IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site 325 332 -
TIGRFAM TIGR00532 HMG_CoA_R_NAD: hydroxymethylglutaryl-CoA reductase, degradative IPR004553 Hydroxymethylglutaryl-CoA reductase, bacterial-type 6 386 4.6E-123
ProSitePatterns PS00066 Hydroxymethylglutaryl-coenzyme A reductases signature 1. IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site 176 190 -
CDD cd00644 HMG-CoA_reductase_classII IPR004553 Hydroxymethylglutaryl-CoA reductase, bacterial-type 8 423 0.0
SUPERFAMILY SSF55035 IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily 111 219 7.85E-32
PRINTS PR00071 Hydroxymethylglutaryl-coenzyme A reductase signature IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II 50 71 1.4E-5
ProSitePatterns PS01192 Hydroxymethylglutaryl-coenzyme A reductases signature 3. IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site 371 384 -
PRINTS PR00071 Hydroxymethylglutaryl-coenzyme A reductase signature IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II 174 192 1.4E-5
Pfam PF00368 Hydroxymethylglutaryl-coenzyme A reductase IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II 16 386 2.5E-109
Gene3D G3DSA:1.10.8.660 376 425 2.2E-13

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.