Burkholderia cenocepacia J2315, BCAL3439 (proB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004349 glutamate 5-kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00902
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005737 cytoplasm
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000729
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003723 RNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01472
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006561 proline biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00902
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
KEGG bcj00332 Carbapenem biosynthesis 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG (InterPro) 00332 Carbapenem biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00330 Arginine and proline metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj00330 Arginine and proline metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01110 Biosynthesis of secondary metabolites 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc L-<i>N<sup>&delta;</sup></i>-acetylornithine biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc L-proline biosynthesis III InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj01230 Biosynthesis of amino acids 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01130 Biosynthesis of antibiotics 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Hamap MF_00456 Glutamate 5-kinase [proB]. IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase 9 263 36.62
PRINTS PR00474 Glutamate 5-kinase family signature IPR001057 Glutamate/acetylglutamate kinase 80 108 1.2E-49
Pfam PF00696 Amino acid kinase family IPR001048 Aspartate/glutamate/uridylate kinase 9 238 2.1E-45
Pfam PF01472 PUA domain IPR002478 PUA domain 281 355 3.2E-22
Gene3D G3DSA:3.40.1160.10 IPR036393 Acetylglutamate kinase-like superfamily 1 269 4.9E-95
PRINTS PR00474 Glutamate 5-kinase family signature IPR001057 Glutamate/acetylglutamate kinase 213 233 1.2E-49
SMART SM00359 IPR002478 PUA domain 281 364 2.9E-16
SUPERFAMILY SSF88697 IPR015947 PUA-like superfamily 281 371 1.16E-24
SUPERFAMILY SSF53633 IPR036393 Acetylglutamate kinase-like superfamily 9 259 3.27E-70
TIGRFAM TIGR01027 proB: glutamate 5-kinase IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase 9 370 1.0E-130
PIRSF PIRSF000729 IPR011529 Glutamate 5-kinase 4 372 1.0E-133
ProSitePatterns PS00902 Glutamate 5-kinase signature. IPR019797 Glutamate 5-kinase, conserved site 211 228 -
Gene3D G3DSA:2.30.130.10 IPR036974 PUA domain superfamily 270 372 1.0E-32
PRINTS PR00474 Glutamate 5-kinase family signature IPR001057 Glutamate/acetylglutamate kinase 152 179 1.2E-49
ProSiteProfiles PS50890 PUA domain profile. IPR002478 PUA domain 280 358 16.952
PRINTS PR00474 Glutamate 5-kinase family signature IPR001057 Glutamate/acetylglutamate kinase 120 141 1.2E-49
CDD cd04242 AAK_G5K_ProB IPR041739 Glutamate-5-kinase domain 10 257 1.7224E-127
PRINTS PR00474 Glutamate 5-kinase family signature IPR001057 Glutamate/acetylglutamate kinase 46 60 1.2E-49

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.