Burkholderia cenocepacia J2315, BCAL2096 (ligA)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0003677	DNA binding	ISM Inferred from Sequence Model Term mapped from: InterPro:SM00278	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006260	DNA replication	ISM Inferred from Sequence Model Term mapped from: InterPro:PF03120	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006281	DNA repair	ISM Inferred from Sequence Model Term mapped from: InterPro:PF03120	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003911	DNA ligase (NAD+) activity	ISM Inferred from Sequence Model Term mapped from: InterPro:cd00114	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	bcj03430	Mismatch repair	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bcj03030	DNA replication	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bcj03420	Nucleotide excision repair	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bcj03410	Base excision repair	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Pfam	PF12826	Helix-hairpin-helix motif	IPR041663	DisA/LigA, helix-hairpin-helix motif	527	590	3.3E-27
Gene3D	G3DSA:3.30.470.90				78	334	1.6E-95
SUPERFAMILY	SSF52113		IPR036420	BRCT domain superfamily	610	687	1.64E-20
SUPERFAMILY	SSF56091				13	333	3.2E-116
PIRSF	PIRSF001604		IPR001679	NAD-dependent DNA ligase	5	690	6.7E-250
Gene3D	G3DSA:1.10.150.20				449	521	6.4E-29
SMART	SM00278		IPR003583	Helix-hairpin-helix DNA-binding motif, class 1	497	516	150.0
SUPERFAMILY	SSF50249		IPR012340	Nucleic acid-binding, OB-fold	335	416	1.71E-28
CDD	cd00114	LIGANc	IPR013839	NAD-dependent DNA ligase, adenylation	15	334	4.03553E-166
ProSitePatterns	PS01056	NAD-dependent DNA ligase signature 2.	IPR033136	NAD-dependent DNA ligase, conserved site	348	363	-
Pfam	PF14520	Helix-hairpin-helix domain			464	519	4.8E-4
SUPERFAMILY	SSF47781		IPR010994	RuvA domain 2-like	420	597	1.07E-65
Gene3D	G3DSA:2.40.50.140				335	406	1.4E-33
SMART	SM00278		IPR003583	Helix-hairpin-helix DNA-binding motif, class 1	463	482	86.0
Pfam	PF03119	NAD-dependent DNA ligase C4 zinc finger domain	IPR004149	Zinc-finger, NAD-dependent DNA ligase C4-type	424	451	6.8E-12
ProSiteProfiles	PS50172	BRCT domain profile.	IPR001357	BRCT domain	610	691	15.927
Pfam	PF03120	NAD-dependent DNA ligase OB-fold domain	IPR004150	NAD-dependent DNA ligase, OB-fold	339	415	1.4E-35
ProSitePatterns	PS01055	NAD-dependent DNA ligase signature 1.	IPR018239	NAD-dependent DNA ligase, active site	132	161	-
Pfam	PF01653	NAD-dependent DNA ligase adenylation domain	IPR013839	NAD-dependent DNA ligase, adenylation	15	335	4.0E-123
SMART	SM00532		IPR013840	NAD-dependent DNA ligase, N-terminal	12	465	1.0E-263
SMART	SM00292		IPR001357	BRCT domain	612	689	4.6E-16
Pfam	PF00533	BRCA1 C Terminus (BRCT) domain	IPR001357	BRCT domain	612	685	6.8E-14
CDD	cd17748	BRCT_DNA_ligase_like			615	685	4.98406E-30
TIGRFAM	TIGR00575	dnlj: DNA ligase, NAD-dependent	IPR001679	NAD-dependent DNA ligase	20	681	1.3E-257
Gene3D	G3DSA:2.20.70.80				408	448	7.6E-20
Hamap	MF_01588	DNA ligase [ligA].	IPR001679	NAD-dependent DNA ligase	11	686	54.952
SMART	SM00278		IPR003583	Helix-hairpin-helix DNA-binding motif, class 1	561	580	2.9
Gene3D	G3DSA:1.10.287.610				11	76	5.3E-28
Gene3D	G3DSA:1.10.150.20				522	595	5.5E-30
Gene3D	G3DSA:3.40.50.10190		IPR036420	BRCT domain superfamily	596	688	3.9E-29

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.