Burkholderia cenocepacia J2315, BCAL0869 (ilvA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0030170 pyridoxal phosphate binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00165
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004794 L-threonine ammonia-lyase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01124
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006520 cellular amino acid metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00165
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009097 isoleucine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01124
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
KEGG (InterPro) 00260 Glycine, serine and threonine metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj01230 Biosynthesis of amino acids 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01130 Biosynthesis of antibiotics 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01200 Carbon metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj00260 Glycine, serine and threonine metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01110 Biosynthesis of secondary metabolites 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj00290 Valine, leucine and isoleucine biosynthesis 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG (InterPro) 00290 Valine, leucine and isoleucine biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.40.50.1100 15 321 1.9E-136
CDD cd04906 ACT_ThrD-I_1 332 415 4.87248E-44
Pfam PF00585 C-terminal regulatory domain of Threonine dehydratase IPR001721 Threonine dehydratase, ACT-like domain 424 506 5.8E-24
TIGRFAM TIGR01124 ilvA_2Cterm: threonine ammonia-lyase, biosynthetic IPR005787 Threonine dehydratase, biosynthetic 5 506 2.0E-250
Pfam PF00585 C-terminal regulatory domain of Threonine dehydratase IPR001721 Threonine dehydratase, ACT-like domain 323 412 7.7E-31
ProSiteProfiles PS51672 ACT-like domain profile. IPR001721 Threonine dehydratase, ACT-like domain 333 404 14.101
ProSiteProfiles PS51672 ACT-like domain profile. IPR001721 Threonine dehydratase, ACT-like domain 427 498 17.613
CDD cd01562 Thr-dehyd 7 314 1.01922E-152
CDD cd04907 ACT_ThrD-I_2 426 506 1.78629E-45
SUPERFAMILY SSF53686 IPR036052 Tryptophan synthase beta subunit-like PLP-dependent enzyme 5 360 6.42E-98
ProSitePatterns PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site 43 56 -
SUPERFAMILY SSF55021 413 506 5.49E-27
Pfam PF00291 Pyridoxal-phosphate dependent enzyme IPR001926 Pyridoxal-phosphate dependent enzyme 18 310 3.4E-79
Gene3D G3DSA:3.40.1020.10 IPR038110 Threonine dehydratase, ACT-like domain superfamily 332 507 7.5E-75
Gene3D G3DSA:3.40.50.1100 51 150 1.9E-136

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.