Burkholderia cenocepacia J2315, BCAL0710 (lipA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SFLDS00029
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016992 lipoate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SFLDF00271
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051536 iron-sulfur cluster binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SFLDS00029
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SFLDF00271
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009107 lipoate biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SFLDF00271
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
KEGG (InterPro) 00785 Lipoic acid metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc lipoate biosynthesis and incorporation III (Bacillus) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj00785 Lipoic acid metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc lipoate biosynthesis and incorporation (yeast) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
MobiDBLite mobidb-lite consensus disorder prediction 1 23 -
SUPERFAMILY SSF102114 60 325 2.88E-68
SMART SM00729 IPR006638 Elp3/MiaB/NifB 93 302 6.3E-19
SFLD SFLDF00271 lipoyl synthase IPR003698 Lipoyl synthase 42 324 0.0
PIRSF PIRSF005963 IPR003698 Lipoyl synthase 5 328 2.9E-133
SFLD SFLDS00029 Radical SAM IPR007197 Radical SAM 42 324 0.0
CDD cd01335 Radical_SAM 103 295 7.0383E-11
Pfam PF04055 Radical SAM superfamily IPR007197 Radical SAM 100 260 7.2E-17
Gene3D G3DSA:3.20.20.70 IPR013785 Aldolase-type TIM barrel 89 303 3.3E-21
Hamap MF_00206 Lipoyl synthase [lipA]. IPR003698 Lipoyl synthase 45 330 155.306
Pfam PF16881 N-terminal domain of lipoyl synthase of Radical_SAM family IPR031691 Lipoyl synthase, N-terminal 41 82 3.6E-9
TIGRFAM TIGR00510 lipA: lipoyl synthase IPR003698 Lipoyl synthase 42 325 4.9E-132

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.