Burkholderia cenocepacia J2315, BCAL0681 (metH1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0031419 cobalamin binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02310
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0044237 cellular metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.20.20.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0046872 metal ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02310
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008705 methionine synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008270 zinc ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0042558 pteridine-containing compound metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS50972
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009086 methionine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
MetaCyc folate transformations I InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00670 One carbon pool by folate InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj00450 Selenocompound metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01110 Biosynthesis of secondary metabolites 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG (InterPro) 00450 Selenocompound metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj00270 Cysteine and methionine metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc L-methionine biosynthesis IV (archaea) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc folate transformations II InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00270 Cysteine and methionine metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj00670 One carbon pool by folate 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01230 Biosynthesis of amino acids 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
ProSiteProfiles PS51332 B12-binding domain profile. IPR006158 Cobalamin (vitamin B12)-binding domain 420 559 42.549
Pfam PF02607 B12 binding domain IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 322 399 1.3E-24
CDD cd00740 MeTr 22 278 9.06792E-132
Pfam PF02965 Vitamin B12 dependent methionine synthase, activation domain IPR004223 Vitamin B12-dependent methionine synthase, activation domain 615 889 1.4E-121
CDD cd02069 methionine_synthase_B12_BD IPR033706 Methionine synthase, B12-binding domain 322 549 2.30752E-131
PIRSF PIRSF000381 IPR011822 Cobalamin-dependent methionine synthase 1 878 0.0
TIGRFAM TIGR02082 metH: methionine synthase IPR011822 Cobalamin-dependent methionine synthase 4 875 0.0
SUPERFAMILY SSF52242 IPR036724 Cobalamin-binding domain superfamily 416 572 1.57E-42
SMART SM01018 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 320 407 7.0E-42
Gene3D G3DSA:3.10.196.10 IPR037010 Vitamin B12-dependent methionine synthase, activation domain superfamily 585 905 1.3E-134
SUPERFAMILY SSF47644 IPR036594 Methionine synthase domain 315 406 1.44E-26
Pfam PF00809 Pterin binding enzyme IPR000489 Pterin-binding domain 26 264 7.0E-61
Coils Coil 558 578 -
SUPERFAMILY SSF51717 IPR011005 Dihydropteroate synthase-like 22 296 4.06E-94
Gene3D G3DSA:3.20.20.20 IPR011005 Dihydropteroate synthase-like 6 308 4.0E-134
ProSiteProfiles PS50972 Pterin-binding domain profile. IPR000489 Pterin-binding domain 22 283 32.059
Pfam PF02310 B12 binding domain IPR006158 Cobalamin (vitamin B12)-binding domain 422 515 2.4E-16
ProSiteProfiles PS51337 B12-binding N-terminal domain profile. IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 313 411 37.023
SUPERFAMILY SSF56507 IPR037010 Vitamin B12-dependent methionine synthase, activation domain superfamily 579 905 1.83E-122
Gene3D G3DSA:1.10.1240.10 IPR036594 Methionine synthase domain 312 404 6.6E-38
Gene3D G3DSA:1.10.288.10 614 776 1.3E-134
ProSiteProfiles PS50974 AdoMet activation domain profile. IPR004223 Vitamin B12-dependent methionine synthase, activation domain 574 905 83.852
Gene3D G3DSA:3.40.50.280 417 573 1.8E-53

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.