Burkholderia thailandensis E264 ATCC 700388, BTH_II2093 (malF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0031177 phosphopantetheine binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00823
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.40.47.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
TIGRFAM TIGR01746 Thioester-redct: thioester reductase domain IPR010080 Thioester reductase-like domain 3657 4021 3.5E-76
SUPERFAMILY SSF52777 2861 3035 2.78E-33
Gene3D G3DSA:3.30.559.10 IPR023213 Chloramphenicol acetyltransferase-like domain superfamily 2861 3223 8.5E-108
SUPERFAMILY SSF47336 IPR036736 ACP-like superfamily 2746 2838 1.31E-13
Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain IPR014031 Beta-ketoacyl synthase, C-terminal 379 504 7.7E-41
Gene3D G3DSA:3.40.47.10 IPR016039 Thiolase-like 2131 2709 8.5E-235
ProSitePatterns PS00606 Beta-ketoacyl synthases active site. IPR018201 Beta-ketoacyl synthase, active site 2276 2292 -
SUPERFAMILY SSF51735 IPR036291 NAD(P)-binding domain superfamily 1277 1518 3.78E-31
CDD cd02440 AdoMet_MTases 1752 1857 1.53516E-5
ProSiteProfiles PS50075 Carrier protein (CP) domain profile. IPR009081 Phosphopantetheine binding ACP domain 2746 2821 13.893
SUPERFAMILY SSF53901 IPR016039 Thiolase-like 2126 2540 2.03E-85
SMART SM00823 Phosphopantetheine attachment site IPR020806 Polyketide synthase, phosphopantetheine-binding domain 15 86 1.6E-7
Gene3D G3DSA:3.40.47.10 IPR016039 Thiolase-like 136 715 7.2E-204
SUPERFAMILY SSF53901 IPR016039 Thiolase-like 131 554 9.71E-86
CDD cd08953 KR_2_SDR_x 1169 1502 4.71749E-73
Pfam PF16197 Ketoacyl-synthetase C-terminal extension IPR032821 Ketoacyl-synthetase, C-terminal extension 508 616 7.9E-15
SMART SM00826 IPR020807 Polyketide synthase, dehydratase domain 718 955 1.1E-5
SMART SM00823 Phosphopantetheine attachment site IPR020806 Polyketide synthase, phosphopantetheine-binding domain 3556 3625 8.6E-5
SUPERFAMILY SSF51735 IPR036291 NAD(P)-binding domain superfamily 3657 3970 1.48E-40
Pfam PF16197 Ketoacyl-synthetase C-terminal extension IPR032821 Ketoacyl-synthetase, C-terminal extension 2491 2601 1.9E-12
SUPERFAMILY SSF47336 IPR036736 ACP-like superfamily 7 86 8.38E-13
SMART SM01294 1990 2056 1.2E-4
CDD cd05235 SDR_e1 IPR010080 Thioester reductase-like domain 3658 3914 3.72035E-73
Gene3D G3DSA:3.40.50.720 1070 1512 7.7E-79
SMART SM00823 Phosphopantetheine attachment site IPR020806 Polyketide synthase, phosphopantetheine-binding domain 1989 2060 3.5E-15
Gene3D G3DSA:3.30.559.30 3039 3278 8.5E-108
ProSiteProfiles PS50075 Carrier protein (CP) domain profile. IPR009081 Phosphopantetheine binding ACP domain 1983 2060 13.718
Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain IPR014031 Beta-ketoacyl synthase, C-terminal 2372 2488 2.4E-38
SMART SM00823 Phosphopantetheine attachment site IPR020806 Polyketide synthase, phosphopantetheine-binding domain 2752 2821 2.6E-6
Pfam PF00668 Condensation domain IPR001242 Condensation domain 2859 3281 1.1E-66
Pfam PF08659 KR domain IPR013968 Polyketide synthase, ketoreductase domain 1282 1460 2.0E-36
Gene3D G3DSA:1.10.1200.10 IPR036736 ACP-like superfamily 2740 2820 2.1E-14
Gene3D G3DSA:1.10.1200.10 IPR036736 ACP-like superfamily 1974 2063 8.2E-22
Gene3D G3DSA:3.30.70.3050 625 695 7.2E-204
Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain IPR014030 Beta-ketoacyl synthase, N-terminal 2130 2363 9.2E-81
SUPERFAMILY SSF53335 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase 1684 1909 3.02E-24
MobiDBLite mobidb-lite consensus disorder prediction 793 807 -
MobiDBLite mobidb-lite consensus disorder prediction 116 130 -
MobiDBLite mobidb-lite consensus disorder prediction 778 829 -
Pfam PF00550 Phosphopantetheine attachment site IPR009081 Phosphopantetheine binding ACP domain 1990 2055 6.1E-15
Gene3D G3DSA:3.40.50.720 3640 4026 6.8E-86
Gene3D G3DSA:1.10.1200.10 IPR036736 ACP-like superfamily 3541 3627 2.5E-22
SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1282 1462 6.0E-28
Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain IPR014030 Beta-ketoacyl synthase, N-terminal 135 371 7.2E-81
Pfam PF00550 Phosphopantetheine attachment site IPR009081 Phosphopantetheine binding ACP domain 3559 3620 3.7E-11
SUPERFAMILY SSF47336 IPR036736 ACP-like superfamily 3548 3621 1.7E-16
ProSiteProfiles PS50075 Carrier protein (CP) domain profile. IPR009081 Phosphopantetheine binding ACP domain 5 86 8.695
CDD cd00833 PKS 135 554 0.0
Pfam PF14765 Polyketide synthase dehydratase IPR020807 Polyketide synthase, dehydratase domain 837 1068 4.9E-24
MobiDBLite mobidb-lite consensus disorder prediction 2824 2855 -
ProSiteProfiles PS50075 Carrier protein (CP) domain profile. IPR009081 Phosphopantetheine binding ACP domain 3550 3625 16.516
ProSitePatterns PS00606 Beta-ketoacyl synthases active site. IPR018201 Beta-ketoacyl synthase, active site 284 300 -
Pfam PF00550 Phosphopantetheine attachment site IPR009081 Phosphopantetheine binding ACP domain 2755 2817 1.6E-9
Pfam PF00550 Phosphopantetheine attachment site IPR009081 Phosphopantetheine binding ACP domain 17 82 8.0E-7
SUPERFAMILY SSF47336 IPR036736 ACP-like superfamily 1987 2142 7.98E-15
SMART SM00825 Beta-ketoacyl synthase IPR020841 Polyketide synthase, beta-ketoacyl synthase domain 136 559 5.4E-188
Gene3D G3DSA:3.30.70.3290 2554 2693 8.5E-235
CDD cd00833 PKS 2133 2539 0.0
Pfam PF07993 Male sterility protein IPR013120 Male sterility, NAD-binding 3659 3897 2.1E-55
ProSitePatterns PS00012 Phosphopantetheine attachment site. IPR006162 Phosphopantetheine attachment site 2015 2030 -
SMART SM00825 Beta-ketoacyl synthase IPR020841 Polyketide synthase, beta-ketoacyl synthase domain 2131 2544 8.4E-184
MobiDBLite mobidb-lite consensus disorder prediction 99 130 -
Gene3D G3DSA:3.40.50.150 1712 1914 2.6E-47
Pfam PF08242 Methyltransferase domain IPR013217 Methyltransferase type 12 1752 1855 6.8E-14
SUPERFAMILY SSF51735 IPR036291 NAD(P)-binding domain superfamily 1080 1267 7.87E-16
Gene3D G3DSA:1.10.1200.10 IPR036736 ACP-like superfamily 1 87 9.3E-15
SUPERFAMILY SSF52777 3042 3277 3.0E-51

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.