Burkholderia thailandensis E264 ATCC 700388, BTH_II2088 (malA)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds	ISM Inferred from Sequence Model Term mapped from: InterPro:SM00824	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0031177	phosphopantetheine binding	ISM Inferred from Sequence Model Term mapped from: InterPro:SM00823	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0009058	biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:SM00824	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:G3DSA:3.40.47.10	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0016740	transferase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:G3DSA:3.40.366.10	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Pfam	PF00975	Thioesterase domain	IPR001031	Thioesterase	1947	2167	5.1E-13
Gene3D	G3DSA:3.40.47.10		IPR016039	Thiolase-like	909	1359	2.8E-141
SMART	SM00823	Phosphopantetheine attachment site	IPR020806	Polyketide synthase, phosphopantetheine-binding domain	817	886	3.5E-4
CDD	cd00833	PKS			914	1354	1.21002E-156
SMART	SM00825	Beta-ketoacyl synthase	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	914	1359	3.4E-139
SUPERFAMILY	SSF51735		IPR036291	NAD(P)-binding domain superfamily	2191	2373	5.9E-10
ProSitePatterns	PS00012	Phosphopantetheine attachment site.	IPR006162	Phosphopantetheine attachment site	2741	2756	-
Pfam	PF02801	Beta-ketoacyl synthase, C-terminal domain	IPR014031	Beta-ketoacyl synthase, C-terminal	1173	1298	1.4E-34
Gene3D	G3DSA:3.40.50.1820		IPR029058	Alpha/Beta hydrolase fold	1911	2180	2.6E-27
Gene3D	G3DSA:1.10.1200.10		IPR036736	ACP-like superfamily	800	889	1.6E-21
Gene3D	G3DSA:3.30.70.3290				1375	1838	5.5E-107
Pfam	PF00109	Beta-ketoacyl synthase, N-terminal domain	IPR014030	Beta-ketoacyl synthase, N-terminal	913	1164	4.7E-59
SUPERFAMILY	SSF53474		IPR029058	Alpha/Beta hydrolase fold	13	250	4.88E-42
Pfam	PF16197	Ketoacyl-synthetase C-terminal extension	IPR032821	Ketoacyl-synthetase, C-terminal extension	1331	1421	1.5E-13
ProSitePatterns	PS00012	Phosphopantetheine attachment site.	IPR006162	Phosphopantetheine attachment site	841	856	-
ProSitePatterns	PS00455	Putative AMP-binding domain signature.	IPR020845	AMP-binding, conserved site	434	445	-
SMART	SM00822	This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.			2387	2553	1.3E-18
Gene3D	G3DSA:3.30.300.30				692	799	5.9E-20
Pfam	PF00550	Phosphopantetheine attachment site	IPR009081	Phosphopantetheine binding ACP domain	2738	2774	2.6E-4
MobiDBLite	mobidb-lite	consensus disorder prediction			789	812	-
Pfam	PF08659	KR domain	IPR013968	Polyketide synthase, ketoreductase domain	2387	2552	2.2E-31
SUPERFAMILY	SSF55048		IPR016036	Malonyl-CoA ACP transacylase, ACP-binding	1604	1667	1.7E-8
SUPERFAMILY	SSF47336		IPR036736	ACP-like superfamily	815	882	1.57E-15
Gene3D	G3DSA:3.40.366.10		IPR001227	Acyl transferase domain superfamily	1467	1788	5.5E-107
SUPERFAMILY	SSF56801				287	824	1.44E-102
ProSitePatterns	PS00606	Beta-ketoacyl synthases active site.	IPR018201	Beta-ketoacyl synthase, active site	1079	1095	-
SUPERFAMILY	SSF51735		IPR036291	NAD(P)-binding domain superfamily	2386	2569	2.05E-26
Pfam	PF00975	Thioesterase domain	IPR001031	Thioesterase	17	240	9.6E-38
CDD	cd05930	A_NRPS			301	793	2.67058E-109
MobiDBLite	mobidb-lite	consensus disorder prediction			2660	2677	-
SMART	SM00824	Thioesterase	IPR020802	Polyketide synthase, thioesterase domain	19	251	1.3E-5
SUPERFAMILY	SSF47336		IPR036736	ACP-like superfamily	2720	2782	1.7E-5
Gene3D	G3DSA:3.40.50.12780		IPR042099	AMP-dependent synthetase-like superfamily	280	691	2.2E-85
SUPERFAMILY	SSF53901		IPR016039	Thiolase-like	910	1354	1.87E-72
Gene3D	G3DSA:3.40.50.720				2181	2630	9.6E-61
ProSiteProfiles	PS50075	Carrier protein (CP) domain profile.	IPR009081	Phosphopantetheine binding ACP domain	811	886	15.652
Pfam	PF13193	AMP-binding enzyme C-terminal domain	IPR025110	AMP-binding enzyme, C-terminal domain	707	777	2.2E-6
Pfam	PF00698	Acyl transferase domain	IPR014043	Acyl transferase	1468	1758	3.6E-39
SUPERFAMILY	SSF53474		IPR029058	Alpha/Beta hydrolase fold	1920	2178	1.53E-22
Gene3D	G3DSA:3.40.50.1820		IPR029058	Alpha/Beta hydrolase fold	2	248	3.3E-55
SMART	SM00827	Acyl transferase domain in polyketide synthase (PKS) enzymes.	IPR020801	Polyketide synthase, acyl transferase domain	1469	1782	5.5E-78
Pfam	PF00501	AMP-binding enzyme	IPR000873	AMP-dependent synthetase/ligase	294	698	3.2E-67
SUPERFAMILY	SSF52151		IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	1466	1758	4.45E-57
Pfam	PF00550	Phosphopantetheine attachment site	IPR009081	Phosphopantetheine binding ACP domain	819	881	7.2E-13
MobiDBLite	mobidb-lite	consensus disorder prediction			2630	2716	-

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.