Burkholderia cenocepacia J2315, BCAM1857 (tecA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM1857
NCBI Locus TagQU43_RS63685
Name
tecA
Replicon chromosome 2
Genomic location 2076087 - 2076566 (- strand)

Cross-References

RefSeq WP_006489887.1
GI 206563705
Entrez 6929491
GI 206563705
INSDC CAR55715.1
NCBI Locus Tag QU43_RS63685
NCBI Old Locus Tag BCAM1857
RefSeq WP_006489887.1,GeneID
UniParc UPI00017BA05A
UniProtKB Acc B4EMB9
UniProtKB ID B4EMB9_BURCJ
UniRef100 UniRef100_B4EMB9
UniRef50 UniRef50_A0A071M8X0
UniRef90 UniRef90_A0A095FX05

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system effector protein TecA
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 2.91
Kyte-Doolittle Hydrophobicity Value -0.046
Molecular Weight (kDa) 17031.1
Isoelectric Point (pI) 9.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
Western blot evidence
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category T6SS
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes
Reference 27133449

Pathogen Association Analysis

Results
Pathogenic
Found only in pathogenic strains
Hits to this gene were found in 3 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG006635 (186 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM1857
Search term: tecA

References

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation.
Aubert DF, Xu H, Yang J, Shi X, Gao W, Li L, Bisaro F, Chen S, Valvano MA, Shao F
Cell Host Microbe 2016 May 11;19(5):664-74
PubMed ID: 27133449