Burkholderia cenocepacia J2315, BCAM1711 (paaK2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM1711
NCBI Locus TagQU43_RS62950
Name
paaK2
Synonym: paaK
Replicon chromosome 2
Genomic location 1907386 - 1908708 (- strand)

Cross-References

RefSeq WP_006483970.1
GI 206563560
Entrez 6929350
GI 206563560
INSDC CAR55568.1
NCBI Locus Tag QU43_RS62950
NCBI Old Locus Tag BCAM1711
RefSeq WP_006483970.1,GeneID
UniParc UPI00017BA241
UniProtKB Acc B4EL89
UniProtKB ID B4EL89_BURCJ
UniRef100 UniRef100_B4EL89
UniRef50 UniRef50_Q9L9C1
UniRef90 UniRef90_B4EL89

Product

Feature Type CDS
Coding Frame 1
Product Name
Paak2
Product Name Confidence: Class 1
Synonyms phenylacetate-coenzyme A ligase
Evidence for Translation
Charge (pH 7) -4.43
Kyte-Doolittle Hydrophobicity Value -0.147
Molecular Weight (kDa) 48042.4
Isoelectric Point (pI) 6.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2Y4O LIGASE 01/07/11 Crystal Structure of PaaK2 in complex with phenylacetyl adenylate BURKHOLDERIA CENOCEPACIA 1.9 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 320 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003587 (315 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM1711
Search term: paaK2
Search term: Paak2

References

Defining a structural and kinetic rationale for paralogous copies of phenylacetate-CoA ligases from the cystic fibrosis pathogen Burkholderia cenocepacia J2315.
Law A, Boulanger MJ
J Biol Chem 2011 Apr 29;286(17):15577-85
PubMed ID: 21388965