Burkholderia cenocepacia J2315, BCAM1349

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM1349
NCBI Locus TagQU43_RS61105
Name
Replicon chromosome 2
Genomic location 1499028 - 1499810 (+ strand)

Cross-References

RefSeq WP_006494985.1
GI 206563201
Entrez 6929015
GI 206563201
INSDC CAR55206.1
NCBI Locus Tag QU43_RS61105
NCBI Old Locus Tag BCAM1349
RefSeq WP_006494985.1,GeneID
UniParc UPI00017BA11D
UniProtKB Acc B4EIC5
UniProtKB ID B4EIC5_BURCJ
UniRef100 UniRef100_A0A095GNG3
UniRef50 UniRef50_A0A069PT98
UniRef90 UniRef90_A0A071MGB0

Product

Feature Type CDS
Coding Frame 1
Product Name
CRP/FNR family transcriptional regulator
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 6.70
Kyte-Doolittle Hydrophobicity Value -0.160
Molecular Weight (kDa) 28659.8
Isoelectric Point (pI) 8.62

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 78 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003321 (610 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM1349

Human Homologs

References

The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia.
Fazli M, O'Connell A, Nilsson M, Niehaus K, Dow JM, Givskov M, Ryan RP, Tolker-Nielsen T
Mol Microbiol 2011 Oct;82(2):327-41
PubMed ID: 21883527
The exopolysaccharide gene cluster Bcam1330-Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c-di-GMP and Bcam1349.
Fazli M, McCarthy Y, Givskov M, Ryan RP, Tolker-Nielsen T
Microbiologyopen 2013 Feb;2(1):105-22
PubMed ID: 23281338