Burkholderia cenocepacia J2315, BCAL3132 (rmlD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL3132
NCBI Locus TagQU43_RS52380
Name
rmlD
Replicon chromosome 1
Genomic location 3423824 - 3424747 (- strand)

Cross-References

RefSeq YP_002232241.1
GI 206561476
Entrez 6934259
GI 206561476
INSDC CAR53455.1
NCBI Locus Tag QU43_RS52380
NCBI Old Locus Tag BCAL3132
RefSeq YP_002232241.1
UniParc UPI00017B9993
UniProtKB Acc B4ECS3
UniProtKB ID B4ECS3_BURCJ
UniRef100 UniRef100_B4ECS3
UniRef50 UniRef50_Q2SYI1
UniRef90 UniRef90_B4ECS3

Product

Feature Type CDS
Coding Frame 1
Product Name
dTDP-4-keto-L-rhamnose reductase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -4.07
Kyte-Doolittle Hydrophobicity Value -0.111
Molecular Weight (kDa) 33465.3
Isoelectric Point (pI) 5.43

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database BGD
Category Lipopolysaccharide O antigen
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes rmlD mutant attenuated for virulence in agar bead model of chronic lung infection
Reference 15213146

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 504 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000733 (642 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL3132
Search term: rmlD

Human Homologs

Ensembl 97, assembly GRCh38.p12
methionine adenosyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:6905]
E-value: 2.8e-17
Percent Identity: 31.1
Ensembl 97, assembly GRCh38.p12
methionine adenosyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:6905]
E-value: 2.8e-17
Percent Identity: 31.1

References

A new route to dTDP-6-deoxy-l-talose and dTDP-L-rhamnose: dTDP-L-rhamnose 4-epimerase in Burkholderia thailandensis.
Yoo HG, Kwon SY, Karki S, Kwon HJ
Bioorg Med Chem Lett 2011 Jul 1;21(13):3914-7
PubMed ID: 21640586