Strain |
Burkholderia cenocepacia J2315
GCF_000009485.1|latest |
Locus Tag |
BCAL2820
|
NCBI Locus Tag | QU43_RS50715 |
Name |
oprM
|
Replicon | chromosome 1 |
Genomic location | 3095788 - 3097311 (- strand) |
Comment | Major RND-4 substrates are aztreonam, chloramphenicol, fluoroquinolones, tobramycin |
Comment | Member of rnd-4 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-4 |
RefSeq | WP_012492848.1 |
GI | 206561157 |
Entrez | 6932820 |
GI | 206561157 |
INSDC | CAR53120.1 |
NCBI Locus Tag | QU43_RS50715 |
NCBI Old Locus Tag | BCAL2820 |
RefSeq | WP_012492848.1,GeneID |
UniParc | UPI00017B997F |
UniProtKB Acc | B4EA04 |
UniProtKB ID | B4EA04_BURCJ |
UniRef100 | UniRef100_B4EA04 |
UniRef50 | UniRef50_Q2T5R7 |
UniRef90 | UniRef90_B4EA04 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
RND-4 efflux system outer membrane protein
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -1.30 |
Kyte-Doolittle Hydrophobicity Value | -0.151 |
Molecular Weight (kDa) | 54273.6 |
Isoelectric Point (pI) | 6.33 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 319 genera
|
Burkholderia Ortholog Group |
BG002467 (654 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BCAL2820
Search term: oprM
Search term: RND-4 efflux system outer membrane protein
|
Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance.
Buroni S, Pasca MR, Flannagan RS, Bazzini S, Milano A, Bertani I, Venturi V, Valvano MA, Riccardi G
BMC Microbiol 2009 Sep 17;9:200
PubMed ID: 19761586
|
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825
|