Burkholderia cenocepacia J2315, BCAL1538 (hfq2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL1538
NCBI Locus TagQU43_RS44200
Name
hfq2
Replicon chromosome 1
Genomic location 1704035 - 1704601 (- strand)

Cross-References

RefSeq WP_012492570.1
GI 206559904
Entrez 6931813
GI 206559904
INSDC CAR51837.1
NCBI Locus Tag QU43_RS44200
NCBI Old Locus Tag BCAL1538
RefSeq WP_012492570.1,GeneID
UniParc UPI00017B948F
UniProtKB Acc B4E834
UniProtKB ID B4E834_BURCJ
UniRef100 UniRef100_B4E834
UniRef50 UniRef50_Q140R2
UniRef90 UniRef90_B4E834

Product

Feature Type CDS
Coding Frame 1
Product Name
Hfq2
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 8.68
Kyte-Doolittle Hydrophobicity Value -1.115
Molecular Weight (kDa) 20116.9
Isoelectric Point (pI) 10.24

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 272 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001358 (652 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL1538
Search term: hfq2
Search term: Hfq2

Human Homologs

References

The second RNA chaperone, Hfq2, is also required for survival under stress and full virulence of Burkholderia cenocepacia J2315.
Ramos CG, Sousa SA, Grilo AM, Feliciano JR, Leitão JH
J Bacteriol 2011 Apr;193(7):1515-26
PubMed ID: 21278292
The hfq gene is required for stress resistance and full virulence of Burkholderia cepacia to the nematode Caenorhabditis elegans.
Sousa SA, Ramos CG, Moreira LM, Leitão JH
Microbiology 2010 Mar;156(Pt 3):896-908
PubMed ID: 19942656
Experimental identification of small non-coding regulatory RNAs in the opportunistic human pathogen Burkholderia cenocepacia J2315.
Ramos CG, Grilo AM, da Costa PJ, Leitão JH
Genomics 2013 Feb;101(2):139-48
PubMed ID: 23142676