Burkholderia cenocepacia J2315, BCAL0338 (tssK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0338
NCBI Locus TagQU43_RS38225
Name
tssK
Synonym: bcsO
Replicon chromosome 1
Genomic location 363794 - 365140 (- strand)
CommentPart of the T6SS gene cluster

Cross-References

RefSeq WP_006477098.1
GI 206558744
Entrez 6930883
GI 206558744
INSDC CAR50648.1
NCBI Locus Tag QU43_RS38225
NCBI Old Locus Tag BCAL0338
RefSeq WP_006477098.1,GeneID
UniParc UPI000052DD51
UniProtKB Acc B4E6R0
UniProtKB ID B4E6R0_BURCJ
UniRef100 UniRef100_B1JUN4
UniRef50 UniRef50_A0A031GUJ4
UniRef90 UniRef90_A0A0B6RHV8

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssK
Product Name Confidence: Class 1
Synonyms putative type VI secretion system protein TssK
Evidence for Translation
Charge (pH 7) -10.92
Kyte-Doolittle Hydrophobicity Value -0.040
Molecular Weight (kDa) 49904.3
Isoelectric Point (pI) 5.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 108 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000363 (632 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0338
Search term: tssK

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the type VI secretion system.
Zoued A, Durand E, Bebeacua C, Brunet YR, Douzi B, Cambillau C, Cascales E, Journet L
J Biol Chem 2013 Sep 20;288(38):27031-41
PubMed ID: 23921384
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149