Burkholderia thailandensis E264 ATCC 700388, BTH_I2955 (tagF-1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_I2955
NCBI Locus TagBTH_RS27265
Name
tagF-1
Replicon chromosome I
Genomic location 3400200 - 3401189 (+ strand)
Transposon Mutants 4 transposon mutants in E264 ATCC 700388
CommentThis gene is part of cluster known as the type VI secretion system gene cluster tss-1 based on naming convention used for B. pseudomallei described in PMID:17660433, however unlike B. pseudomallei, the numbers following the vgrG and hcp gene match the cluster number (PMID:20865170).

Cross-References

RefSeq YP_443462.1
GI 83718465
Entrez 3847000
GI 83718465
INSDC AIP28508.1
NCBI Locus Tag BTH_RS27265
NCBI Old Locus Tag BTH_I2955
RefSeq WP_009888606.1
UniParc UPI0000667B93
UniProtKB Acc Q2SUD7
UniProtKB ID Q2SUD7_BURTA
UniRef100 UniRef100_Q2SUD7
UniRef50 UniRef50_D8N088
UniRef90 UniRef90_Q2SUD7

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system-associated protein TagF-1
Product Name Confidence: Class 2
Synonyms TagF-1
hypothetical protein
Evidence for Translation
Charge (pH 7) -3.87
Kyte-Doolittle Hydrophobicity Value -0.026
Molecular Weight (kDa) 36152.9
Isoelectric Point (pI) 6.45

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 17 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000377 (643 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_I2955
Search term: tagF-1

References

Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.
Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD
PLoS Pathog 2010 Aug 26;6(8):e1001068
PubMed ID: 20865170
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434