Burkholderia thailandensis E264; ATCC 700388, BTH_II0132

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264; ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II0132
NCBI Locus TagBTH_RS00675
Name
Replicon chromosome II
Genomic location 157593 - 158975 (- strand)
Transposon Mutants 3 transposon mutants in E264; ATCC 700388
CommentThis gene is part of cluster known as the type VI secretion system gene cluster tss-2 based on naming convention used for B. pseudomallei described in PMID:17660433, however unlike B. pseudomallei, the numbers following the vgrG and hcp gene match the cluster number (PMID:20865170).

Cross-References

RefSeq YP_438334.1
GI 83716926
Entrez 3846142
GI 83716926
INSDC ABC34815.1
NCBI Locus Tag BTH_RS00675
NCBI Old Locus Tag BTH_II0132
RefSeq YP_438334.1
UniParc UPI00006675C1
UniProtKB Acc Q2T915
UniProtKB ID Q2T915_BURTA
UniRef100 UniRef100_Q2T915
UniRef50 UniRef50_A0A095RN58
UniRef90 UniRef90_A0A095SMW1

Product

Feature Type CDS
Coding Frame 1
Product Name
hypothetical protein
Synonyms
Evidence for Translation
Charge (pH 7) -2.94
Kyte-Doolittle Hydrophobicity Value -0.422
Molecular Weight (kDa) 52838.8
Isoelectric Point (pI) 6.77

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 15 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020421 (331 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II0132

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434
Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.
Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD.
PLoS Pathog. 2010 Aug 26;6(8)
PubMed ID: 20865170