Burkholderia pseudomallei K96243, BPSS1541 (bsaS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1541
Name
bsaS
Replicon chromosome 2
Genomic location 2093755 - 2095062 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq YP_111547.1
GI 53722562
Entrez 3096673
GI 53722562
INSDC CAH39014.1
NCBI Locus Tag BPSS1541
RefSeq YP_111547.1,GeneID
UniParc UPI000043BD27
UniProtKB Acc Q63K25
UniProtKB ID Q63K25_BURPS
UniRef100 UniRef100_A0A097XK16
UniRef50 UniRef50_P0A1C1
UniRef90 UniRef90_A3MCF9

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system ATPase BsaS (T3SS-3)
Product Name Confidence: Class 1
Synonyms ATP synthase SpaL
Evidence for Translation
Charge (pH 7) -2.68
Kyte-Doolittle Hydrophobicity Value -0.095
Molecular Weight (kDa) 46800.6
Isoelectric Point (pI) 6.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 666 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019845 (322 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1541
Search term: bsaS

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
Burkholderia pseudomallei type III secretion system cluster 3 ATPase BsaS, a chemotherapeutic target for small-molecule ATPase inhibitors.
Gong L, Lai SC, Treerat P, Prescott M, Adler B, Boyce JD, Devenish RJ
Infect Immun 2015 Apr;83(4):1276-85
PubMed ID: 25605762
Identification of a regulatory cascade controlling Type III Secretion System 3 gene expression in Burkholderia pseudomallei.
Sun GW, Chen Y, Liu Y, Tan GY, Ong C, Tan P, Gan YH
Mol Microbiol 2010 May;76(3):677-89
PubMed ID: 20345664