Burkholderia pseudomallei K96243, BPSS0168 (tssL-3)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0168
Name
tssL-3
Replicon chromosome 2
Genomic location 225502 - 226767 (- strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-3 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-4 cluster later (PMID:22007185)

Cross-References

RefSeq YP_110189.1
GI 53721204
Entrez 3096620
GI 53721204
INSDC CAH37613.1
NCBI Locus Tag BPSS0168
RefSeq YP_110189.1,GeneID
UniParc UPI000043B7F8
UniProtKB Acc Q63NY0
UniProtKB ID Q63NY0_BURPS
UniRef100 UniRef100_A0A069B6C2
UniRef50 UniRef50_I1WQC6
UniRef90 UniRef90_I1WQC6

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssL-3 (T6SS-4)
Product Name Confidence: Class 2
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 9.81
Kyte-Doolittle Hydrophobicity Value -0.224
Molecular Weight (kDa) 45925.0
Isoelectric Point (pI) 9.76

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 407 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG016136 (466 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0168
Search term: tssL-3

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434