Burkholderia pseudomallei K96243, BPSL2289 (iscS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2289
Name
iscS
Replicon chromosome 1
Genomic location 2756180 - 2757403 (- strand)

Cross-References

RefSeq YP_108885.1
GI 53719899
Entrez 3094249
GI 53719899
INSDC CAH36292.1
NCBI Locus Tag BPSL2289
RefSeq YP_108885.1,GeneID
UniParc UPI000043B314
UniProtKB Acc Q63SN1
UniProtKB ID Q63SN1_BURPS
UniRef100 UniRef100_A0A069B9I3
UniRef50 UniRef50_Q486Z0
UniRef90 UniRef90_A1V5M6

Product

Feature Type CDS
Coding Frame 1
Product Name
cysteine desulfurase
Synonyms
Evidence for Translation
Charge (pH 7) -10.22
Kyte-Doolittle Hydrophobicity Value -0.279
Molecular Weight (kDa) 45454.3
Isoelectric Point (pI) 5.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 652 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002019 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2289
Search term: iscS

Human Homologs

Ensembl 97, assembly GRCh38.p12
NFS1 cysteine desulfurase [Source:HGNC Symbol;Acc:HGNC:15910]
E-value: 3.9e-144
Percent Identity: 59.8

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268