Burkholderia pseudomallei K96243, BPSL0793 (ilvE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL0793
Name
ilvE
Replicon chromosome 1
Genomic location 920427 - 921350 (- strand)

Cross-References

RefSeq YP_107418.1
GI 53718432
Entrez 3093889
GI 53718432
INSDC CAH34785.1
NCBI Locus Tag BPSL0793
RefSeq YP_107418.1,GeneID
UniParc UPI000043AD64
UniProtKB Acc Q63WU8
UniProtKB ID Q63WU8_BURPS
UniRef100 UniRef100_A0A069AYP9
UniRef50 UniRef50_Q2T0T3
UniRef90 UniRef90_Q2T0T3

Product

Feature Type CDS
Coding Frame 1
Product Name
branched-chain amino acid aminotransferase
Synonyms
Evidence for Translation
Charge (pH 7) -2.13
Kyte-Doolittle Hydrophobicity Value -0.225
Molecular Weight (kDa) 33985.3
Isoelectric Point (pI) 6.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3U0G TRANSFERASE 09/28/11 Crystal structure of branched-chain amino acid aminotransferase from burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 1.9 X-RAY DIFFRACTION 100.0
4WHX TRANSFERASE 09/23/14 X-ray Crystal Structure of an Amino Acid Aminotransferase from Burkholderia pseudomallei Bound to the Co-factor Pyridoxal Phosphate BURKHOLDERIA PSEUDOMALLEI 576 2.05 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 604 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002490 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL0793
Search term: ilvE

Human Homologs

Ensembl 97, assembly GRCh38.p12
branched chain amino acid transaminase 2 [Source:HGNC Symbol;Acc:HGNC:977]
E-value: 3.4e-15
Percent Identity: 27.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
branched chain amino acid transaminase 2 [Source:HGNC Symbol;Acc:HGNC:977]
E-value: 3.4e-15
Percent Identity: 27.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
branched chain amino acid transaminase 2 [Source:HGNC Symbol;Acc:HGNC:977]
E-value: 3.4e-15
Percent Identity: 27.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
branched chain amino acid transaminase 2 [Source:HGNC Symbol;Acc:HGNC:977]
E-value: 3.4e-15
Percent Identity: 27.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
branched chain amino acid transaminase 2 [Source:HGNC Symbol;Acc:HGNC:977]
E-value: 3.4e-15
Percent Identity: 27.6

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268