Burkholderia cenocepacia H111, I35_RS01725 (tssC)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia H111
Locus Tag
NCBI Old Locus TagI35_0333%2CI35_0384
Synonym: bcsK
Replicon chromosome 1
Genomic location 352412 - 353902 (+ strand)
CommentPart of the T6SS gene cluster


RefSeq WP_006484397.1
GI 493530385
NCBI Locus Tag I35_RS01725
NCBI Old Locus Tag I35_0333%2CI35_0384
RefSeq WP_006484397.1


Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssC
Product Name Confidence: Class 1
Synonyms type VI secretion protein EvpB
Evidence for Translation
Charge (pH 7) -14.45
Kyte-Doolittle Hydrophobicity Value -0.278
Molecular Weight (kDa) 54822.0
Isoelectric Point (pI) 5.01

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000367 (656 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: I35_RS01725
Search term: tssC


A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
BcsKC is an essential protein for the type VI secretion system activity in Burkholderia cenocepacia that forms an outer membrane complex with BcsLB.
Aubert D, MacDonald DK, Valvano MA
J Biol Chem 2010 Nov 12;285(46):35988-98
PubMed ID: 20729192
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149