Strain |
Burkholderia cenocepacia J2315
GCF_000009485.1|latest |
Locus Tag |
BCAM0223
|
NCBI Locus Tag | QU43_RS55535 |
Name |
|
Replicon | chromosome 2 |
Genomic location | 270927 - 275579 (- strand) |
Comment | A BCAM0223::Tp mutant was deficient in hemagglutination, affected in adherence to vitronectin and in biofilm formation and showed attenuated virulence in the Galleria mellonella model of infection. |
RefSeq | YP_002232856.1 |
GI | 206562093 |
Entrez | 6928018 |
GI | 206562093 |
INSDC | CAR54081.1 |
NCBI Locus Tag | QU43_RS55535 |
RefSeq | WP_006489568.1,GeneID |
UniParc | UPI00017B9DF8 |
UniProtKB Acc | B4EHQ5 |
UniProtKB ID | B4EHQ5_BURCJ |
UniRef100 | UniRef100_A0A0D1DGE5 |
UniRef50 | UniRef50_A0A0D1DGE5 |
UniRef90 | UniRef90_A0A0D1DGE5 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
vitronectin-binding trimeric autotransporter adhesin
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -63.77 |
Kyte-Doolittle Hydrophobicity Value | -0.087 |
Molecular Weight (kDa) | 152052.8 |
Isoelectric Point (pI) | 4.09 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 88 genera
|
Burkholderia Ortholog Group |
BG002926 (1913 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BCAM0223
Search term: vitronectin-binding trimeric autotransporter adhesin
|
A BCAM0223 mutant of Burkholderia cenocepacia is deficient in hemagglutination, serum resistance, adhesion to epithelial cells and virulence.
Mil-Homens D, Fialho AM
PLoS One 2012;7(7):e41747
PubMed ID: 22848588
|
Trimeric autotransporter adhesins in members of the Burkholderia cepacia complex: a multifunctional family of proteins implicated in virulence.
Mil-Homens D, Fialho AM
Front Cell Infect Microbiol 2011;1:13
PubMed ID: 22919579
|
Genome-wide analysis of DNA repeats in Burkholderia cenocepacia J2315 identifies a novel adhesin-like gene unique to epidemic-associated strains of the ET-12 lineage.
Mil-Homens D, Rocha EPC, Fialho AM
Microbiology 2010 Apr;156(Pt 4):1084-1096
PubMed ID: 20019083
|