Burkholderia thailandensis E264 ATCC 700388, BTH_II1285 (ribA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II1285
NCBI Locus TagBTH_RS06575
Name
ribA
Replicon chromosome II
Genomic location 1529945 - 1530601 (- strand)
Transposon Mutants 1 transposon mutants in E264 ATCC 700388
CommentMember of the toxoflavin-like gene cluster

Cross-References

RefSeq YP_439481.1
GI 83717720
Entrez 3845058
GI 83717720
INSDC ABC35609.1
NCBI Locus Tag BTH_RS06575
NCBI Old Locus Tag BTH_II1285
RefSeq YP_439481.1
UniParc UPI00006678C1
UniProtKB Acc Q2T5R8
UniProtKB ID Q2T5R8_BURTA
UniRef100 UniRef100_Q2T5R8
UniRef50 UniRef50_Q9KSJ3
UniRef90 UniRef90_A2RWY4

Product

Feature Type CDS
Coding Frame 1
Product Name
GTP cyclohydrolase II
Synonyms
Evidence for Translation
Charge (pH 7) 2.80
Kyte-Doolittle Hydrophobicity Value -0.285
Molecular Weight (kDa) 24358.5
Isoelectric Point (pI) 8.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 486 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG018054 (348 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II1285
Search term: ribA

Human Homologs

References

Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Fenwick MK, Almabruk KH, Ealick SE, Begley TP, Philmus B
Biochemistry 2017 Aug 1;56(30):3934-3944
PubMed ID: 28665591