Burkholderia pseudomallei K96243, BPSS1492 (bimA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1492
Name
bimA
Replicon chromosome 2
Genomic location 2033784 - 2035334 (+ strand)

Cross-References

RefSeq YP_111499.1
GI 53722514
Entrez 3097017
GI 53722514
NCBI Locus Tag BPSS1492
RefSeq YP_111499.1,GeneID
UniProtKB Acc Q63K73
UniProtKB ID Q63K73_BURPS

Product

Feature Type CDS
Coding Frame 1
Product Name
Burkholderia intracellular motility A, BimA
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 3.90
Kyte-Doolittle Hydrophobicity Value -0.338
Molecular Weight (kDa) 51803.2
Isoelectric Point (pI) 9.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database BGD
Category Trimeric autotransporter
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes bimA mutation has reduced net intracellular replication in J774.2 murine macrophage-like cells
Reference 25830295
Source 2
Database VFDB : VF0427
Category Burkholderia intracellular motility A
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 65 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002926 (1913 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1492
Search term: bimA

Human Homologs

References

Identification of a bacterial factor required for actin-based motility of Burkholderia pseudomallei.
Stevens MP, Stevens JM, Jeng RL, Taylor LA, Wood MW, Hawes P, Monaghan P, Welch MD, Galyov EE
Mol Microbiol 2005 Apr;56(1):40-53
PubMed ID: 15773977