Burkholderia pseudomallei K96243, BPSL3106 (tssC-1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
BPSL3106
Name
tssC-1
Replicon chromosome 1
Genomic location 3711217 - 3712707 (- strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-1 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-1 cluster later (PMID:22007185)

Cross-References

RefSeq YP_109701.1
GI 53720715
Entrez 3093076
GI 53720715
INSDC CAH37117.1
NCBI Locus Tag BPSL3106
RefSeq YP_109701.1,GeneID
UniParc UPI000043B61C
UniProtKB Acc Q63QB7
UniProtKB ID Q63QB7_BURPS
UniRef100 UniRef100_A0A069B925
UniRef50 UniRef50_A0A0B6RY49
UniRef90 UniRef90_A0A0B6RY49

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssC-1
Product Name Confidence: Class 2
Synonyms hypothetical protein
Evidence for Translation
Detected in B. pseudomallei strain DD503 using trypsin shaving and mass spectrometry (PMID:21391724). Found in at least two preparations.
Charge (pH 7) -15.69
Kyte-Doolittle Hydrophobicity Value -0.252
Molecular Weight (kDa) 54767.0
Isoelectric Point (pI) 4.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization
Detected in Triton-insoluble fraction of lysozyme-treated B. pseudomallei DD503 cells using trypsin shaving and mass spectrometry (PMID:21391724).

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 111 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000367 (656 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL3106
Search term: tssC-1

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434