Burkholderia pseudomallei K96243, BPSL3100 (tssA-1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
BPSL3100
Name
tssA-1
Replicon chromosome 1
Genomic location 3703205 - 3704326 (- strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-1 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-1 cluster later (PMID:22007185)

Cross-References

RefSeq YP_109695.1
GI 53720709
Entrez 3093360
GI 53720709
INSDC CAH37111.1
NCBI Locus Tag BPSL3100
RefSeq YP_109695.1,GeneID
UniParc UPI000043B616
UniProtKB Acc Q63QC3
UniProtKB ID Q63QC3_BURPS
UniRef100 UniRef100_Q63QC3
UniRef50 UniRef50_A1UZK2
UniRef90 UniRef90_A1UZK2

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssA-1
Product Name Confidence: Class 2
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -20.63
Kyte-Doolittle Hydrophobicity Value -0.346
Molecular Weight (kDa) 40936.3
Isoelectric Point (pI) 4.55

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 76 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000373 (645 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL3100
Search term: tssA-1

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434