Burkholderia pseudomallei K96243, BPSL2938 (leuS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF09334
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004823 leucine-tRNA ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00396
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006418 tRNA aminoacylation for protein translation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF09334
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0000166 nucleotide binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF09334
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0002161 aminoacyl-tRNA editing activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF13603
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006429 leucyl-tRNA aminoacylation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00396
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004812 aminoacyl-tRNA ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF09334
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
KEGG bps00970 Aminoacyl-tRNA biosynthesis 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG (InterPro) 00970 Aminoacyl-tRNA biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Coils Coil 864 864 -
Gene3D G3DSA:3.10.330.110 571 633 0.0
PRINTS PR00985 Leucyl-tRNA synthetase signature IPR002302 Leucine-tRNA ligase 491 509 6.1E-47
SUPERFAMILY SSF52374 7 672 5.05E-142
TIGRFAM TIGR00396 leuS_bact: leucine--tRNA ligase IPR002302 Leucine-tRNA ligase 8 864 0.0
Pfam PF08264 Anticodon-binding domain of tRNA IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 704 826 1.9E-16
ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site 42 53 -
Pfam PF09334 tRNA synthetases class I (M) IPR015413 Methionyl/Leucyl tRNA synthetase 38 171 1.5E-19
Gene3D G3DSA:1.10.730.10 8 796 0.0
SUPERFAMILY SSF50677 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain 225 419 3.24E-48
Gene3D G3DSA:3.10.20.590 805 864 1.3E-18
PRINTS PR00985 Leucyl-tRNA synthetase signature IPR002302 Leucine-tRNA ligase 185 198 6.1E-47
Gene3D G3DSA:3.40.50.620 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold 33 570 0.0
Pfam PF13603 Leucyl-tRNA synthetase, Domain 2 IPR025709 Leucyl-tRNA synthetase, editing domain 220 407 2.4E-66
SUPERFAMILY SSF47323 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding 668 864 1.4E-32
Pfam PF00133 tRNA synthetases class I (I, L, M and V) IPR002300 Aminoacyl-tRNA synthetase, class Ia 623 663 8.4E-6
PRINTS PR00985 Leucyl-tRNA synthetase signature IPR002302 Leucine-tRNA ligase 214 233 6.1E-47
Hamap MF_00049_B Leucine--tRNA ligase [leuS]. IPR002302 Leucine-tRNA ligase 4 864 22.383
PRINTS PR00985 Leucyl-tRNA synthetase signature IPR002302 Leucine-tRNA ligase 153 169 6.1E-47
Gene3D G3DSA:3.90.740.10 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain 226 418 0.0
Pfam PF00133 tRNA synthetases class I (I, L, M and V) IPR002300 Aminoacyl-tRNA synthetase, class Ia 421 576 1.4E-8
PRINTS PR00985 Leucyl-tRNA synthetase signature IPR002302 Leucine-tRNA ligase 561 571 6.1E-47
CDD cd00812 LeuRS_core 34 663 1.37717E-84
PRINTS PR00985 Leucyl-tRNA synthetase signature IPR002302 Leucine-tRNA ligase 127 144 6.1E-47
PRINTS PR00985 Leucyl-tRNA synthetase signature IPR002302 Leucine-tRNA ligase 528 550 6.1E-47
CDD cd07958 Anticodon_Ia_Leu_BEm 663 778 3.24163E-36

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.