Burkholderia pseudomallei K96243, BPSL2758 (glyA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Biological Process | GO:0035999 | tetrahydrofolate interconversion |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000412
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0003824 | catalytic activity |
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.40.640.10
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0035999 | tetrahydrofolate interconversion |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000412
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000412
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0004372 | glycine hydroxymethyltransferase activity |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000412
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0003824 | catalytic activity |
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.40.640.10
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0019264 | glycine biosynthetic process from serine |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000412
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0004372 | glycine hydroxymethyltransferase activity |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000412
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000412
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0019264 | glycine biosynthetic process from serine |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000412
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| KEGG | bps01200 | Carbon metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps00460 | Cyanoamino acid metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | glycine betaine degradation II (mammalian) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | folate polyglutamylation | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG | bps01130 | Biosynthesis of antibiotics | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | folate transformations II | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | purine nucleobases degradation II (anaerobic) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG (InterPro) | 00460 | Cyanoamino acid metabolism | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| MetaCyc | folate transformations I | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG | bps01110 | Biosynthesis of secondary metabolites | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | glycine betaine degradation I | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | formaldehyde assimilation I (serine pathway) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG | bps00630 | Glyoxylate and dicarboxylate metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps00670 | One carbon pool by folate | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps00260 | Glycine, serine and threonine metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps01100 | Metabolic pathways | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps01120 | Microbial metabolism in diverse environments | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps01230 | Biosynthesis of amino acids | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps00680 | Methane metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG (InterPro) | 00630 | Glyoxylate and dicarboxylate metabolism | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| MetaCyc | photorespiration | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG (InterPro) | 00670 | One carbon pool by folate | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| KEGG (InterPro) | 00260 | Glycine, serine and threonine metabolism | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| KEGG (InterPro) | 00680 | Methane metabolism | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| SUPERFAMILY | SSF53383 | IPR015424 | Pyridoxal phosphate-dependent transferase | 6 | 414 | 2.18E-182 | |
| ProSitePatterns | PS00096 | Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. | IPR019798 | Serine hydroxymethyltransferase, pyridoxal phosphate binding site | 222 | 238 | - |
| Gene3D | G3DSA:3.90.1150.10 | IPR015422 | Pyridoxal phosphate-dependent transferase domain 1 | 11 | 392 | 1.2E-186 | |
| Hamap | MF_00051 | Serine hydroxymethyltransferase [glyA]. | IPR001085 | Serine hydroxymethyltransferase | 8 | 415 | 52.846 |
| CDD | cd00378 | SHMT | IPR001085 | Serine hydroxymethyltransferase | 10 | 407 | 0.0 |
| Pfam | PF00464 | Serine hydroxymethyltransferase | IPR039429 | Serine hydroxymethyltransferase-like domain | 10 | 384 | 1.7E-175 |
| PIRSF | PIRSF000412 | IPR001085 | Serine hydroxymethyltransferase | 1 | 415 | 5.6E-171 | |
| Gene3D | G3DSA:3.40.640.10 | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain | 38 | 287 | 1.2E-186 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.