Burkholderia cenocepacia J2315, BCAL2944 (hldD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAL2944
NCBI Locus TagQU43_RS51365
Name
hldD
Replicon chromosome 1
Genomic location 3222190 - 3223182 (- strand)

Cross-References

RefSeq WP_006486849.1
GI 206561279
Entrez 6932891
GI 206561279
INSDC CAR53245.1
NCBI Locus Tag QU43_RS51365
NCBI Old Locus Tag BCAL2944
RefSeq WP_006486849.1,GeneID
UniParc UPI00017B9731
UniProtKB Acc B4EB34
UniProtKB ID HLDD_BURCJ
UniRef100 UniRef100_B4EB34
UniRef50 UniRef50_Q9HYQ8
UniRef90 UniRef90_P0DMK5

Product

Feature Type CDS
Coding Frame 1
Product Name
ADP-l-glycero-D-manno-heptose-6-epimerase
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -2.16
Kyte-Doolittle Hydrophobicity Value -0.301
Molecular Weight (kDa) 37218.7
Isoelectric Point (pI) 6.16

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Lipopolysaccharide core region
Evidence ECO:0000316
genetic interaction evidence used in manual assertion
Host Organism Rattus norvegicus
Notes hldA-/hdlD- mutant does not survive in the rat agar bead model of chronic lung infection
Reference 16513737

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 599 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000895 (678 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL2944
Search term: hldD

References

A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.
Loutet SA, Flannagan RS, Kooi C, Sokol PA, Valvano MA.
J Bacteriol. 2006 Mar;188(6):2073-80.
PubMed ID: 16513737