Burkholderia cenocepacia J2315, BCAL1861 (phbB)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL1861
NCBI Locus Tag	QU43_RS45850
Name	phbB
Replicon	chromosome 1
Genomic location	2051988 - 2052728 (- strand)

Cross-References

RefSeq	WP_006491801.1
GI	206560224
Entrez	6933931
GI	206560224
INSDC	CAR52161.1
NCBI Locus Tag	QU43_RS45850
NCBI Old Locus Tag	BCAL1861
RefSeq	WP_006491801.1,GeneID
UniParc	UPI000052E6F6
UniProtKB Acc	B4EAG0
UniProtKB ID	B4EAG0_BURCJ
UniRef100	UniRef100_A0A071MUF4
UniRef50	UniRef50_G0EZ44
UniRef90	UniRef90_Q3JRS9

Product

Feature Type	CDS
Coding Frame	1
Product Name	acetyacetyl-CoA reductase
Synonyms
Evidence for Translation
Charge (pH 7)	-0.34
Kyte-Doolittle Hydrophobicity Value	-0.100
Molecular Weight (kDa)	26289.7
Isoelectric Point (pI)	6.79

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
5VML	OXIDOREDUCTASE	04/27/17	Crystal Structure of Acetoacetyl-CoA Reductase from Burkholderia Pseudomallei 1710b with bound NADP	BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B)	1.7	X-RAY DIFFRACTION	95.1
3EZL	OXIDOREDUCTASE	10/23/08	Crystal Structure of Acetoacetyl-CoA Reductase from Burkholderia Pseudomallei 1710b	BURKHOLDERIA PSEUDOMALLEI 1710B	2.25	X-RAY DIFFRACTION	95.1

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 652 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG001626 (653 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL1861 Search term: phbB Search term: acetyacetyl-CoA reductase

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000305438 hydroxysteroid 17-beta dehydrogenase 13 [Source:HGNC Symbol;Acc:HGNC:18685] E-value: 5.8e-10 Percent Identity: 28.0

References