Burkholderia glumae BGR1, bglu_2g14490 (tofI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia glumae BGR1
GCF_000022645.2|latest
Locus Tag
bglu_2g14490
NCBI Locus TagBGLU_RS24865
Name
tofI
Replicon chromosome 2
Genomic location 1848865 - 1849476 (+ strand)

Cross-References

RefSeq WP_015877501.1
GI
Entrez 7904925
NCBI Locus Tag BGLU_RS24865
NCBI Old Locus Tag bglu_2g14490
RefSeq WP_015877501.1,GeneID

Product

Feature Type CDS
Coding Frame 1
Product Name
TofI
Synonyms
Evidence for Translation
Charge (pH 7) -6.50
Kyte-Doolittle Hydrophobicity Value -0.103
Molecular Weight (kDa) 22407.1
Isoelectric Point (pI) 5.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3P2H SIGNALING PROTEIN/Inhibitor 10/02/10 Crystal structure of TofI in a ternary complex with an inhibitor and MTA BURKHOLDERIA GLUMAE 2.0 X-RAY DIFFRACTION 97.5
3P2F SIGNALING PROTEIN 10/02/10 Crystal structure of TofI in an apo form BURKHOLDERIA GLUMAE 2.3 X-RAY DIFFRACTION 97.5

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 63 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003720 (981 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: bglu_2g14490
Search term: tofI
Search term: TofI

Human Homologs

References

Dissection of quorum-sensing genes in Burkholderia glumae reveals non-canonical regulation and the new regulatory gene tofM for toxoflavin production.
Chen R, Barphagha IK, Karki HS, Ham JH
PLoS One 2012;7(12):e52150
PubMed ID: 23284909