Burkholderia cenocepacia J2315, BCAS0593

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAS0593
NCBI Locus Tag	QU43_RS71615
Name
Replicon	chromosome 3
Genomic location	649453 - 650880 (+ strand)
Comment	Member of rnd-1 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-1

Cross-References

RefSeq	WP_006489740.1
GI	197295434
Entrez	6804418
GI	197295434
INSDC	CAR57525.1
NCBI Locus Tag	QU43_RS71615
NCBI Old Locus Tag	BCAS0593
RefSeq	WP_006489740.1,GeneID
UniParc	UPI00017BB05C
UniProtKB Acc	B4ENY7
UniProtKB ID	B4ENY7_BURCJ
UniRef100	UniRef100_B4ENY7
UniRef50	UniRef50_Q51487
UniRef90	UniRef90_A0A095FJT3

Product

Feature Type	CDS
Coding Frame	1
Product Name	RND-1 efflux system outer membrane protein Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7)	-2.33
Kyte-Doolittle Hydrophobicity Value	-0.210
Molecular Weight (kDa)	51307.0
Isoelectric Point (pI)	5.89

Subcellular localization

Individual Mappings	Localization Confidence PMID Outer Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 311 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG006899 (65 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAS0593 Search term: RND-1 efflux system outer membrane protein

Human Homologs

References

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance. Buroni S, Pasca MR, Flannagan RS, Bazzini S, Milano A, Bertani I, Venturi V, Valvano MA, Riccardi G BMC Microbiol 2009 Sep 17;9:200 PubMed ID: 19761586

Efflux pump-mediated drug resistance in Burkholderia. Podnecky NL, Rhodes KA, Schweizer HP Front Microbiol 2015;6:305 PubMed ID: 25926825