Burkholderia cenocepacia J2315, BCAS0167 (shc)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAS0167
NCBI Locus TagQU43_RS69505
Name
shc
Replicon chromosome 3
Genomic location 184743 - 186782 (- strand)

Cross-References

RefSeq WP_012493685.1
GI 197295018
Entrez 6804739
GI 197295018
INSDC CAR57099.1
NCBI Locus Tag QU43_RS69505
NCBI Old Locus Tag BCAS0167
RefSeq WP_012493685.1,GeneID
UniParc UPI00017BB1E1
UniProtKB Acc B4EPT3
UniProtKB ID B4EPT3_BURCJ
UniRef100 UniRef100_B4EPT3
UniRef50 UniRef50_A9ASX8
UniRef90 UniRef90_B9BP78

Product

Feature Type CDS
Coding Frame 1
Product Name
squalene-hopene cyclase
Synonyms
Evidence for Translation
Charge (pH 7) 5.78
Kyte-Doolittle Hydrophobicity Value -0.325
Molecular Weight (kDa) 76384.1
Isoelectric Point (pI) 8.01

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 93 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005236 (256 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAS0167
Search term: shc

Human Homologs

References

Spontaneous and evolutionary changes in the antibiotic resistance of Burkholderia cenocepacia observed by global gene expression analysis.
Sass A, Marchbank A, Tullis E, Lipuma JJ, Mahenthiralingam E
BMC Genomics 2011 Jul 22;12:373
PubMed ID: 21781329