Burkholderia cenocepacia J2315, BCAM2551 (ceoA)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM2551
NCBI Locus Tag	QU43_RS67215
Name	ceoA
Replicon	chromosome 2
Genomic location	2896013 - 2897230 (- strand)
Comment	Major substrates of RND-10 are chloramphenicol, flouroquinolones and trimethoprim
Comment	Member of ceoAB-opcM (rnd-10) operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump (RND-10)

Cross-References

RefSeq	WP_006484484.1
GI	206564392
Entrez	6930417
GI	206564392
INSDC	CAR56417.1
NCBI Locus Tag	QU43_RS67215
NCBI Old Locus Tag	BCAM2551
RefSeq	WP_006484484.1,GeneID
UniParc	UPI00017BA3F5
UniProtKB Acc	B4EJQ1
UniProtKB ID	B4EJQ1_BURCJ
UniRef100	UniRef100_B4EJQ1
UniRef50	UniRef50_Q1LDP7
UniRef90	UniRef90_B4EJQ1

Product

Feature Type	CDS
Coding Frame	1
Product Name	multidrug efflux system transport protein CeoA Product Name Confidence: Class 1
Synonyms	RND-10 efflux system membrane fusion protein
Evidence for Translation
Charge (pH 7)	4.73
Kyte-Doolittle Hydrophobicity Value	-0.213
Molecular Weight (kDa)	42843.8
Isoelectric Point (pI)	9.53

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 433 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG004187 (621 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM2551 Search term: ceoA Search term: multidrug efflux system transport protein CeoA

Human Homologs

References

Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia). Nair BM, Cheung KJ Jr, Griffith A, Burns JL J Clin Invest 2004 Feb;113(3):464-73 PubMed ID: 14755343

Efflux pump-mediated drug resistance in Burkholderia. Podnecky NL, Rhodes KA, Schweizer HP Front Microbiol 2015;6:305 PubMed ID: 25926825