Burkholderia cenocepacia J2315, BCAM2551 (ceoA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM2551
NCBI Locus TagQU43_RS67215
Name
ceoA
Replicon chromosome 2
Genomic location 2896013 - 2897230 (- strand)
Comment Major substrates of RND-10 are chloramphenicol, flouroquinolones and trimethoprim
CommentMember of ceoAB-opcM (rnd-10) operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump (RND-10)

Cross-References

RefSeq WP_006484484.1
GI 206564392
Entrez 6930417
GI 206564392
INSDC CAR56417.1
NCBI Locus Tag QU43_RS67215
NCBI Old Locus Tag BCAM2551
RefSeq WP_006484484.1,GeneID
UniParc UPI00017BA3F5
UniProtKB Acc B4EJQ1
UniProtKB ID B4EJQ1_BURCJ
UniRef100 UniRef100_B4EJQ1
UniRef50 UniRef50_Q1LDP7
UniRef90 UniRef90_B4EJQ1

Product

Feature Type CDS
Coding Frame 1
Product Name
multidrug efflux system transport protein CeoA
Product Name Confidence: Class 1
Synonyms RND-10 efflux system membrane fusion protein
Evidence for Translation
Charge (pH 7) 4.73
Kyte-Doolittle Hydrophobicity Value -0.213
Molecular Weight (kDa) 42843.8
Isoelectric Point (pI) 9.53

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 433 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004187 (621 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2551
Search term: ceoA

References

Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia).
Nair BM, Cheung KJ Jr, Griffith A, Burns JL
J Clin Invest 2004 Feb;113(3):464-73
PubMed ID: 14755343
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825