Burkholderia cenocepacia J2315, BCAM2550 (ceoB)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM2550
NCBI Locus Tag	QU43_RS67210
Name	ceoB
Replicon	chromosome 2
Genomic location	2892767 - 2895967 (- strand)
Comment	Major substrates of RND-10 are chloramphenicol, flouroquinolones and trimethoprim
Comment	Member of ceoAB-opcM (rnd-10) operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump (RND-10)

Cross-References

RefSeq	WP_006484500.1
GI	206564391
Entrez	6930570
GI	206564391
INSDC	CAR56416.1
NCBI Locus Tag	QU43_RS67210
NCBI Old Locus Tag	BCAM2550
RefSeq	WP_006484500.1,GeneID
UniParc	UPI00017BA3F4
UniProtKB Acc	B4EJQ0
UniProtKB ID	B4EJQ0_BURCJ
UniRef100	UniRef100_B4EJQ0
UniRef50	UniRef50_Q8EBL9
UniRef90	UniRef90_B4EJQ0

Product

Feature Type	CDS
Coding Frame	1
Product Name	multidrug efflux system transporter protein CeoB Product Name Confidence: Class 1
Synonyms	RND-10 efflux system transporter protein
Evidence for Translation
Charge (pH 7)	4.44
Kyte-Doolittle Hydrophobicity Value	0.310
Molecular Weight (kDa)	114773.5
Isoelectric Point (pI)	8.73

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 488 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG001444 (2569 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM2550 Search term: ceoB Search term: multidrug efflux system transporter protein CeoB

Human Homologs

References

Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia). Nair BM, Cheung KJ Jr, Griffith A, Burns JL J Clin Invest 2004 Feb;113(3):464-73 PubMed ID: 14755343

Efflux pump-mediated drug resistance in Burkholderia. Podnecky NL, Rhodes KA, Schweizer HP Front Microbiol 2015;6:305 PubMed ID: 25926825