Burkholderia cenocepacia J2315, BCAM2235 (pchA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM2235
NCBI Locus TagQU43_RS65540
Name
pchA
Replicon chromosome 2
Genomic location 2505070 - 2506503 (+ strand)

Cross-References

RefSeq WP_006484730.1
GI 206564070
Entrez 6930587
GI 206564070
INSDC CAR56092.1
NCBI Locus Tag QU43_RS65540
NCBI Old Locus Tag BCAM2235
RefSeq WP_006484730.1,GeneID
UniParc UPI00017BA023
UniProtKB Acc B4EGG6
UniProtKB ID B4EGG6_BURCJ
UniRef100 UniRef100_A0A0D1BSQ1
UniRef50 UniRef50_A3NHP9
UniRef90 UniRef90_A0A095EB88

Product

Feature Type CDS
Coding Frame 1
Product Name
salicylate biosynthesis isochorismate synthase
Synonyms
Evidence for Translation
Charge (pH 7) -0.42
Kyte-Doolittle Hydrophobicity Value -0.029
Molecular Weight (kDa) 50956.2
Isoelectric Point (pI) 6.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 598 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001595 (502 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2235
Search term: pchA

Human Homologs

References

Dihydroaeruginoic acid synthetase and pyochelin synthetase, products of the pchEF genes, are induced by extracellular pyochelin in Pseudomonas aeruginosa.
Reimmann C, Serino L, Beyeler M, Haas D
Microbiology 1998 Nov;144 ( Pt 11):3135-48
PubMed ID: 9846750
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103