Burkholderia cenocepacia J2315, BCAM2165 (penB)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM2165
NCBI Locus Tag	QU43_RS65190
Name	penB
Replicon	chromosome 2
Genomic location	2413082 - 2414020 (- strand)

Cross-References

RefSeq	WP_012493495.1
GI	206564002
Entrez	6929758
GI	206564002
INSDC	CAR56023.1
NCBI Locus Tag	QU43_RS65190
NCBI Old Locus Tag	BCAM2165
RefSeq	WP_012493495.1,GeneID
UniParc	UPI00017B9F53
UniProtKB Acc	B4EFW2
UniProtKB ID	B4EFW2_BURCJ
UniRef100	UniRef100_B4EFW2
UniRef50	UniRef50_Q8GD10
UniRef90	UniRef90_B4EFW2

Product

Feature Type	CDS
Coding Frame	1
Product Name	putative beta-lactamase Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7)	4.35
Kyte-Doolittle Hydrophobicity Value	0.077
Molecular Weight (kDa)	32347.4
Isoelectric Point (pI)	8.87

Subcellular localization

Individual Mappings	Localization Confidence PMID Periplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 144 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG003909 (644 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM2165 Search term: penB Search term: putative beta-lactamase

Human Homologs

References

Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. Poirel L, Rodriguez-Martinez JM, Plésiat P, Nordmann P Antimicrob Agents Chemother 2009 Mar;53(3):876-82 PubMed ID: 19075063

Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Trépanier S, Prince A, Huletsky A Antimicrob Agents Chemother 1997 Nov;41(11):2399-405 PubMed ID: 9371340

Erratum in: J Bacteriol. 2009 Apr;191(8):2907. The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients. J Bacteriol. 2009 Jan;191(1):261-77. PubMed ID: 18931103

Cell Wall Recycling-Linked Coregulation of AmpC and PenB β-Lactamases through ampD Mutations in Burkholderia cenocepacia. Hwang J, Kim HS Antimicrob Agents Chemother 2015 Dec;59(12):7602-10 PubMed ID: 26416862