Burkholderia cenocepacia J2315, BCAM1947 (oqxA)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM1947
NCBI Locus Tag	QU43_RS64080
Name	oqxA
Replicon	chromosome 2
Genomic location	2163707 - 2164903 (- strand)
Comment	Major RND-9 substrate is tobramycin, chlorhexidine (in biofilm grown cells)
Comment	Member of rnd-9 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-9

Cross-References

RefSeq	WP_006485134.1
GI	206563792
Entrez	6929578
GI	206563792
INSDC	CAR55806.1
NCBI Locus Tag	QU43_RS64080
NCBI Old Locus Tag	BCAM1947
RefSeq	WP_006485134.1,GeneID
UniParc	UPI00017BA17E
UniProtKB Acc	B4EMT0
UniProtKB ID	B4EMT0_BURCJ
UniRef100	UniRef100_A0A0D1DNR1
UniRef50	UniRef50_Q398J3
UniRef90	UniRef90_Q398J3

Product

Feature Type	CDS
Coding Frame	1
Product Name	RND-9 efflux system outer membrane protein Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7)	1.36
Kyte-Doolittle Hydrophobicity Value	-0.259
Molecular Weight (kDa)	42701.6
Isoelectric Point (pI)	7.59

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 425 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG006645 (184 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM1947 Search term: oqxA Search term: RND-9 efflux system outer membrane protein

Human Homologs

References

Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells. Buroni S, Matthijs N, Spadaro F, Van Acker H, Scoffone VC, Pasca MR, Riccardi G, Coenye T Antimicrob Agents Chemother 2014 Dec;58(12):7424-9 PubMed ID: 25267676

Efflux pump-mediated drug resistance in Burkholderia. Podnecky NL, Rhodes KA, Schweizer HP Front Microbiol 2015;6:305 PubMed ID: 25926825