Strain |
Burkholderia cenocepacia J2315
GCF_000009485.1|latest |
Locus Tag |
BCAM1946
|
NCBI Locus Tag | QU43_RS64075 |
Name |
|
Replicon | chromosome 2 |
Genomic location | 2160520 - 2163693 (- strand) |
Comment | Member of rnd-9 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-9 |
Comment | Major RND-9 substrate is tobramycin, chlorhexidine (in biofilm grown cells) |
RefSeq | WP_006485132.1 |
GI | 206563791 |
Entrez | 6929577 |
GI | 206563791 |
INSDC | CAR55805.1 |
NCBI Locus Tag | QU43_RS64075 |
NCBI Old Locus Tag | BCAM1946 |
RefSeq | WP_006485132.1,GeneID |
UniParc | UPI00017BA17D |
UniProtKB Acc | B4EMS9 |
UniProtKB ID | B4EMS9_BURCJ |
UniRef100 | UniRef100_A0A0D1CER5 |
UniRef50 | UniRef50_Q880Q4 |
UniRef90 | UniRef90_B1K9Q0 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
RND-9 efflux system transporter protein
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | 4.28 |
Kyte-Doolittle Hydrophobicity Value | 0.351 |
Molecular Weight (kDa) | 113414.6 |
Isoelectric Point (pI) | 8.14 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
oqxB | RND efflux pump conferring resistance to fluoroquinolone | ARO:3003923 | protein homolog model | Strict | 0.0 | 71.46 | 1.2.1 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 488 genera
|
Burkholderia Ortholog Group |
BG001444 (2569 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BCAM1946
Search term: RND-9 efflux system transporter protein
|
Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells.
Buroni S, Matthijs N, Spadaro F, Van Acker H, Scoffone VC, Pasca MR, Riccardi G, Coenye T
Antimicrob Agents Chemother 2014 Dec;58(12):7424-9
PubMed ID: 25267676
|
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825
|