Burkholderia cenocepacia J2315, BCAM1868 (cepR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM1868
NCBI Locus TagQU43_RS63740
Name
cepR
Replicon chromosome 2
Genomic location 2086737 - 2087456 (- strand)

Cross-References

RefSeq WP_006483948.1
GI 206563716
Entrez 6929502
GI 206563716
INSDC CAR55726.1
NCBI Locus Tag QU43_RS63740
NCBI Old Locus Tag BCAM1868
RefSeq WP_006483948.1,GeneID
UniParc UPI00017BA09B
UniProtKB Acc B4EMD0
UniProtKB ID B4EMD0_BURCJ
UniRef100 UniRef100_B4EMD0
UniRef50 UniRef50_P58590
UniRef90 UniRef90_B4EMD0

Product

Feature Type CDS
Coding Frame 1
Product Name
N-acylhomoserine lactone dependent regulatory protein CepR
Product Name Confidence: Class 1
Synonyms transcriptional regulator CepR
Evidence for Translation
Charge (pH 7) -3.20
Kyte-Doolittle Hydrophobicity Value -0.054
Molecular Weight (kDa) 26606.1
Isoelectric Point (pI) 5.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 369 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003718 (1367 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM1868
Search term: cepR

Human Homologs

References

Distribution of quorum-sensing genes in the Burkholderia cepacia complex.
Lutter E, Lewenza S, Dennis JJ, Visser MB, Sokol PA
Infect Immun 2001 Jul;69(7):4661-6
PubMed ID: 11402012
Identification of functions linking quorum sensing with biofilm formation in Burkholderia cenocepacia H111.
Inhülsen S, Aguilar C, Schmid N, Suppiger A, Riedel K, Eberl L
Microbiologyopen 2012 Jun;1(2):225-42
PubMed ID: 22950027
The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility.
Huber B, Riedel K, Hentzer M, Heydorn A, Gotschlich A, Givskov M, Molin S, Eberl L
Microbiology 2001 Sep;147(Pt 9):2517-2528
PubMed ID: 11535791